SLC4A7

Entrez Summary: This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Azithromycin 100μM R08 exp452	-2.48
LLY-284 2.6μM R06 exp291	-2.36
Mubritinib 0.2μM R01 exp48	-2.33
WYE-354 6μM R02 exp90	-2.25
GSK-LSD1 10μM R03 exp123	-2.17
Chloramphenicol 20μM R00 exp13	-2.09
ZLN024 50μM R08 exp538	-2.02
Rotenone 20μM R00 exp34	-2
Glyphosate 1000μM R06 exp283	-1.96
Quinacrine 2.5μM R03 exp146	-1.88
Oligomycin-A 2μM R00 exp25	-1.86
FTY720 3μM R08 exp483	-1.85
GSK-J4 1-1.25μM to day4 R07 exp363	-1.83
All-trans-Retinoic-Acid 8μM R07 exp333	-1.77
Nicotine 3000μM R08 exp510	-1.77
NMS-873 0.07μM R07 exp380	-1.77
Thioridazine 5μM R08 exp530	-1.76
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.74
LY2090314 0.003μM R08 exp500 no dilution day6	1.74
Epothilone-B 0.0015μM R05 exp231	1.79
Quercetin 20μM R08 exp517	1.84
GSK626616 14μM R08 exp485	1.85
AICAR 240μM R03 exp116	1.97
Pimelic-diphenylamide-106 5μM R00 exp28	1.99
SB743921 0.001μM R05 exp244	1.99
Aphidicolin 0.4μM R08 exp440	2.12
Aminopterin 0.005μM R07 exp335	2.34
SNS-032 15μM R08 exp443	2.48
CB-5083 0.4μM R08 exp468	2.49
UM0125461 0.74μM R02 exp84	2.49
JQ1 0.8μM R08 exp435	2.55
Bleomycin 5μM R08 exp459	2.62
Ethanol 0.01 R05 exp234	2.74
Sulforaphane 9μM R08 exp526 no dilution day6	2.78
Olaparib 4μM R08 exp512	2.94
Benzoate 20000μM R08 exp456	2.96
2-Deoxy-D-glucose 800μM R05 exp214	3.15
Taxol 0.004μM R03 exp103	3.25
Sulforaphane 9μM R08 exp525	3.39
ML-792 0.2μM R08 exp505	4.25

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	1/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	2/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Band 3 cyto
HCO3 cotransp

sodium:bicarbonate symporter activity
inorganic anion exchanger activity
auditory receptor cell development
inner ear auditory receptor cell differentiation
stereocilium
hair cell differentiation
inner ear receptor cell development
bicarbonate transport
neuroepithelial cell differentiation
columnar/cuboidal epithelial cell development
inner ear receptor cell differentiation
mechanoreceptor differentiation
regulation of intracellular pH
regulation of cellular pH
columnar/cuboidal epithelial cell differentiation
regulation of pH
cellular monovalent inorganic cation homeostasis
monovalent inorganic cation homeostasis
sodium ion transport
inorganic anion transport
epithelial cell development
inner ear development
basolateral plasma membrane
ear development
cytoplasmic vesicle
synapse
anion transmembrane transport
epidermal cell differentiation
apical plasma membrane
monovalent inorganic cation transport
epidermis development
organic anion transport
sensory organ development
anion transport
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
epithelial cell differentiation
cation homeostasis
inorganic ion homeostasis