Quinacrine 2.5μM R03 exp146
Mechanism of Action
Intercalates into DNA and RNA, interferes with transcription and translation
- Class / Subclass 1: Infectious Disease / Antimalarial
- Class / Subclass 2: DNA Damage, Repair and Replication / Intercalating Agent
Technical Notes
Compound References
- PubChem Name: Quinacrine dihydrochloride
- Synonyms: Mepacrine (dihydrochloride); SN-390 (dihydrochloride)
- CAS #: 69-05-6
- PubChem CID: 6239
- IUPAC: 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine;dihydrochloride
- INCHI Name: InChI=1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
- INCHI Key: UDKVBVICMUEIKS-UHFFFAOYSA-N
- Molecular Weight: 472.9
- Canonical SMILES: CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC.Cl.Cl
- Isomeric SMILES: N/A
- Molecular Formula: C23H32Cl3N3O
Compound Supplier
- Supplier Name: Sigma-Aldrich
- Catalog #: Q3251
- Lot #: BCBN9703V
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C23H30ClN3O 400.21502; found 400.21557
Dose Response Curve
- Platform ID: QUINACRINE
- Min: 0.8074; Max: 98.8966
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 1.9289 |
| IC30 | 2.3830 |
| IC40 | 2.8339 |
| IC50 | 3.3224 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 03
- Dose: 2.5µM
- Days of incubation: 8
- Doublings: 6.4
- Numbers of reads: 12378658
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/1 | Scores |
Quinacrine 2.5μM R03 exp146
