JAGN1

Entrez Summary: The protein encoded by this gene is a transmembrane protein. It functions in the early secretory pathway and is necessary for neutrophil differentiation and survival. Mutations in this gene result in severe congenital neutropenia. [provided by RefSeq, Oct 2014].
UniProt Summary: Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils. {ECO:0000269|PubMed:25129144, ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cellular response to tunicamycin
response to tunicamycin
granulocyte colony-stimulating factor signaling pathway
neutrophil differentiation
negative regulation of insulin secretion involved in cellular response to glucose stimulus
granulocyte differentiation
defense response to fungus
negative regulation of insulin secretion
negative regulation of peptide hormone secretion
response to fungus
endoplasmic reticulum organization
regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of hormone secretion
neutrophil migration
granulocyte migration
myeloid leukocyte differentiation
cellular response to antibiotic
myeloid leukocyte migration
negative regulation of protein secretion
negative regulation of peptide secretion
regulation of insulin secretion
negative regulation of protein transport
negative regulation of establishment of protein localization
negative regulation of secretion by cell
regulation of peptide hormone secretion
myeloid cell differentiation
negative regulation of secretion
regulation of hormone secretion
response to antibiotic
leukocyte differentiation
leukocyte migration
endomembrane system organization
regulation of protein secretion
negative regulation of transport
regulation of peptide secretion
neutrophil mediated immunity
myeloid leukocyte mediated immunity
regulation of hormone levels
hemopoiesis
hematopoietic or lymphoid organ development