NFN1 0.4μM R03 exp99
Mechanism of Action
Nitrofuran derivative, candidate ALDH2 inhibitor
- Class / Subclass 1: Infectious Disease / Antibiotic
Technical Notes
Compound References
- PubChem Name: Ethyl 5-ethyl-2-[(5-nitrofuran-2-carbonyl)amino]thiophene-3-carboxylate
- Synonyms: N/A
- CAS #: 219620-36-7
- PubChem CID: 2799305
- IUPAC: ethyl 5-ethyl-2-[(5-nitrofuran-2-carbonyl)amino]thiophene-3-carboxylate
- INCHI Name: InChI=1S/C14H14N2O6S/c1-3-8-7-9(14(18)21-4-2)13(23-8)15-12(17)10-5-6-11(22-10)16(19)20/h5-7H,3-4H2,1-2H3,(H,15,17)
- INCHI Key: OASNGLRREXBINI-UHFFFAOYSA-N
- Molecular Weight: 338.34
- Canonical SMILES: CCC1=CC(=C(S1)NC(=O)C2=CC=C(O2)[N+](=O)[O-])C(=O)OCC
- Isomeric SMILES: N/A
- Molecular Formula: C14H14N2O6S
Compound Supplier
- Supplier Name: Maybridge
- Catalog #: BTB05727SC
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C14H14N2O6S 339.06453; found 339.0634
Dose Response Curve
- Platform ID: NFN1
- Min: -1.7682; Max: 66.1639
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 0.3734 |
| IC30 | 1.2393 |
| IC40 | 3.3135 |
| IC50 | 8.1701 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 03
- Dose: 400nM
- Days of incubation: 8
- Doublings: 7.7
- Numbers of reads: 10101237
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
NFN1 0.4μM R03 exp99
NFN1 0.4μM R03 exp99 vs NFN1 1μM R03 exp100
