CDKL3

Gene Information

Official Symbol: CDKL3
Official Name: cyclin dependent kinase like 3
Aliases and Previous Symbols: N/A
Entrez ID: 51265
UniProt: Q8IVW4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-2.39
ONC212 0.15μM R08 exp513	-2.29
Artemisinin 50μM R08 exp450	-2.16
iCRT14 30μM R08 exp492	-2.09
CB-5083 0.4μM R08 exp468	-1.98
Nicotine 3000μM R08 exp510	-1.86
Nocodazole 0.02μM R00 exp23	-1.71
Golgicide-A 4μM R03 exp122	1.78
Nicotinamide 1000μM R03 exp101	1.89
Rifampicin 30μM R08 exp430	1.92
NFN1 0.4μM R03 exp99	1.94
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	2.1
RO-3307 4.7μM R02 exp80	2.1
5-Fluorouracil 2μM R00 exp1	2.2

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18831
Expression level (log2 read counts): 1.9

Expression Distribution

Pkinase
Pkinase Tyr

dendrite extension
cyclin-dependent protein serine/threonine kinase activity
positive regulation of dendrite morphogenesis
negative regulation of axon extension
neuron projection extension
negative regulation of axonogenesis
positive regulation of dendrite development
developmental cell growth
cell growth
regulation of dendrite morphogenesis
regulation of axon extension
negative regulation of cell morphogenesis involved in differentiation
negative regulation of developmental growth
regulation of extent of cell growth
developmental growth involved in morphogenesis
regulation of dendrite development
negative regulation of neuron projection development
positive regulation of cell morphogenesis involved in differentiation
negative regulation of cell projection organization
regulation of cell size
negative regulation of cell growth
regulation of axonogenesis
negative regulation of neuron differentiation
protein kinase activity
negative regulation of growth
positive regulation of neuron projection development
negative regulation of neurogenesis
regulation of cell morphogenesis involved in differentiation
negative regulation of nervous system development
regulation of developmental growth
negative regulation of cell development
positive regulation of neuron differentiation
regulation of cellular component size
positive regulation of cell projection organization
developmental growth
growth
regulation of cell growth
positive regulation of neurogenesis
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis