Nicotinamide 1000μM R03 exp101 [The Human Chemical-Genetic Interaction Map Project]

NAD biosynthetic precursor, activates SIRT1

Class / Subclass 1: Metabolism / Metabolite

Compound References

PubChem Name: Nicotinamide
Synonyms: Niacinamide; Nicotinic acid amide; Vitamin B3
CAS #: 98-92-0
PubChem CID: 936
IUPAC: pyridine-3-carboxamide
INCHI Name: InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
INCHI Key: DFPAKSUCGFBDDF-UHFFFAOYSA-N
Molecular Weight: 122.12
Canonical SMILES: C1=CC(=CN=C1)C(=O)N
Isomeric SMILES: N/A
Molecular Formula: C6H6N2O

Compound Supplier

Supplier Name: Sigma-Aldrich
Catalog #: N3376
Lot #: N/A

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C6H6N2O 123.05529; found 123.05387

Dose Response Curve

Platform ID: NICOTINAMIDE-N3376
Min: -12.6284; Max: 19.5781

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 03
Dose: 1000µM
Days of incubation: 8
Doublings: 7.9
Numbers of reads: 10766702

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
NFKBIA	-2.67	0.13
PHACTR2	-2.39	0.41
SEMA3F	-2.37	0.41
GNL3	-2.34	0.66
CDIPT	-2.33	0.82
FASTKD5	-2.32	0.74
CTPS1	-2.29	0.76
VPS25	-2.26	0.76
KDSR	-2.25	0.41
KCNIP1	-2.21	0.48
GATAD2B	-2.17	0.46
CBFB	-2.16	0.46
ERMARD	-2.10	0.48
NRROS	-2.10	0.48
GCLC	-2.07	0.65
DPAGT1	-2.06	0.76
USP17L13	-2.05	0.48
SLCO1B7	-2.05	0.48
CCT5	-2.00	0.76
GOLGA3	-1.99	0.61
COX15	-1.99	0.76
SIAH2	-1.95	0.65
EPHB4	-1.93	0.74
MYH3	-1.93	0.74
PRRX2	-1.92	0.66
ALG12	-1.92	0.74
MDGA1	-1.91	0.66
HNRNPCL1	-1.89	0.84
RCBTB2	-1.89	0.74
LCE1F	-1.88	0.69
ZCCHC4	1.94	0.62
TLR6	1.94	0.62
GGA3	1.95	0.62
ZNF428	1.95	0.62
TCTE3	1.95	0.62
MFAP1	1.95	0.62
WNK1	1.96	0.62
TAS2R50	1.97	0.62
OR5P3	1.97	0.62
MRPL46	1.97	0.62
TMC7	1.98	0.62
ZNF816	2.06	0.62
FAM69A	2.10	0.62
RPS19	2.11	0.62
FIBCD1	2.11	0.62
PSMA1	2.14	0.62
TMSB15B	2.14	0.71
PSMD11	2.15	0.62
POLE2	2.16	0.62
SMU1	2.19	0.64
RBM39	2.19	0.73
FGD4	2.21	0.62
PLK4	2.23	0.62
LOC643802	2.26	0.62
GOLGA8H	2.37	0.62
RFC1	2.47	0.62
ANKRD40	2.57	0.62
USP17L19	2.58	0.62
SHFM1	2.59	0.62
CDK12	2.61	0.62

Screen	Correlation	Plot
SGC0649 7μM R03 exp150	0.056	View
Bisphenol F 50μM R08 exp457	0.059	View
DABN 2μM R00 exp16	0.057	View
NN-Diethyl-meta-toluamide 100μM R05 exp237	0.052	View
Metformin 40μM R03 exp132	0.051	View

Last modified: 2026/01/15 21:36
by 127.0.0.1