GNL3

Gene Information

Official Symbol: GNL3
Official Name: G protein nucleolar 3
Aliases and Previous Symbols: N/A
Entrez ID: 26354
UniProt: Q9BVP2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
UniProt Summary: May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12464630, ECO:0000269|PubMed:16012751}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
AICAR 240μM R05 exp211	-2.47
Nicotinamide 1000μM R03 exp101	-2.34
Thimerosal 0.85μM R08 exp529	-1.99
Senexin-A 25μM R07 exp400	-1.92
CR131-b 0.005μM R08 exp474	-1.85
Cincreasin 100μM R08 exp473	1.7
RO-3306 3 to 4μM on day4 R04 exp165	1.75
Nicotine 3000μM R08 exp510	1.86
WYE-354 6μM R02 exp90	2.47

Global Fraction of Cell Lines Where Essential: 108/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	6/28
blood	4/28
bone	0/26
breast	6/33
central nervous system	3/56
cervix	0/4
colorectal	3/17
esophagus	1/13
fibroblast	0/1
gastric	1/16
kidney	5/21
liver	1/20
lung	14/75
lymphocyte	3/16
ovary	3/26
pancreas	2/24
peripheral nervous system	5/16
plasma cell	1/15
prostate	0/1
skin	2/24
soft tissue	4/9
thyroid	0/2
upper aerodigestive	7/22
urinary tract	9/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1529
Expression level (log2 read counts): 7.89

Expression Distribution

MMR HSR1
GN3L Grn1

positive regulation of protein sumoylation
positive regulation of protein localization to chromosome, telomeric region
regulation of protein localization to chromosome, telomeric region
regulation of protein sumoylation
mRNA 5-UTR binding
positive regulation of pri-miRNA transcription by RNA polymerase II
stem cell division
regulation of pri-miRNA transcription by RNA polymerase II
positive regulation of telomere maintenance
regulation of telomere maintenance
positive regulation of protein modification by small protein conjugation or removal
stem cell population maintenance
maintenance of cell number
positive regulation of chromosome organization
positive regulation of DNA metabolic process
regulation of protein modification by small protein conjugation or removal
nuclear body
positive regulation of cellular protein localization
regulation of chromosome organization
regulation of DNA metabolic process
GTP binding
cell division
regulation of cellular protein localization
cell population proliferation
positive regulation of organelle organization
nucleolus
regulation of cellular localization
regulation of protein localization
positive regulation of cellular component organization
positive regulation of transcription by RNA polymerase II
positive regulation of protein modification process
regulation of organelle organization
RNA binding
positive regulation of transcription, DNA-templated
extracellular space
positive regulation of cellular protein metabolic process
regulation of cell population proliferation
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of protein metabolic process