Senexin-A 25μM R07 exp400
Mechanism of Action
Inhibits CDK8, suppresses induction of gene expression
- Class / Subclass 1: Signal Transduction / Kinase Inhibitor
- Class / Subclass 2: Gene Regulation / Transcription Inhibitor
Technical Notes
Compound References
- PubChem Name: 4-(2-Phenylethylamino)quinazoline-6-carbonitrile;hydrochloride
- Synonyms: N/A
- CAS #: 1780390-76-2
- PubChem CID: 90488980
- IUPAC: 4-(2-phenylethylamino)quinazoline-6-carbonitrile;hydrochloride
- INCHI Name: InChI=1S/C17H14N4.ClH/c18-11-14-6-7-16-15(10-14)17(21-12-20-16)19-9-8-13-4-2-1-3-5-13;/h1-7,10,12H,8-9H2,(H,19,20,21);1H
- INCHI Key: POENYXHGUHRXFR-UHFFFAOYSA-N
- Molecular Weight: 310.8
- Canonical SMILES: C1=CC=C(C=C1)CCNC2=NC=NC3=C2C=C(C=C3)C#N.Cl
- Isomeric SMILES: N/A
- Molecular Formula: C17H15ClN4
Compound Supplier
- Supplier Name: Tocris Bioscience
- Catalog #: 4875
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C17H14N4 275.12912; found 275.12926
Dose Response Curve
- Platform ID: Senexin_A
- Min: -11.6276; Max: 42.3607
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 16.7423 |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 07
- Dose: 25µM
- Days of incubation: 8
- Doublings: 3.2
- Numbers of reads: 22291136
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 13/4 | Scores |
Senexin-A 25μM R07 exp400
Senexin-A 25μM R07 exp400 vs iCRT14 30μM R08 exp492
