GPAA1

Entrez Summary: N/A
UniProt Summary: Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. {ECO:0000269|PubMed:9468317}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GPI-anchor transamidase activity
GPI-anchor transamidase complex
attachment of GPI anchor to protein
GPI anchor binding
protein retention in ER lumen
maintenance of protein localization in endoplasmic reticulum
GPI anchor biosynthetic process
GPI anchor metabolic process
maintenance of protein localization in organelle
tubulin binding
glycolipid biosynthetic process
maintenance of protein location in cell
protein lipidation
lipoprotein biosynthetic process
maintenance of location in cell
maintenance of protein location
glycolipid metabolic process
phosphatidylinositol biosynthetic process
liposaccharide metabolic process
lipoprotein metabolic process
membrane lipid biosynthetic process
protein localization to endoplasmic reticulum
maintenance of location
phosphatidylinositol metabolic process
membrane lipid metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
carbohydrate derivative biosynthetic process
protein localization to organelle
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
carbohydrate derivative metabolic process
lipid metabolic process