ISY1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Salinomycin 3.5μM R08 exp521	-1.73
Clomiphene 4.4μM R02 exp68	1.71
Ethanol 0.01 R05 exp234	1.71
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.72
DKK1 89ng/ml R08 exp477	1.73
IL-3 9ng/ml R08 exp493	1.75
UMK57 0.6μM R03 exp107	1.75
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.84
2-Methoxyestradiol 0.2μM R01 exp40	1.85
Cidofovir 10μM R07 exp345	1.87
Nifuroxazide 1μM R01 exp51	1.89
Glyphosate 1000μM R06 exp283	1.94
Myriocin 25μM R06 exp293	1.95
A-769662 20μM R07 exp331	2.1
Hydroxychloroquine 30μM R08 exp490	2.1
Prochlorperazine 5.2μM R02 exp77	2.23
CCT251545 0.2μM R06 exp271	2.27
Senexin-A 25μM R07 exp400	2.32
ABT-702 5μM R07 exp318	2.38
Betulinic acid 10 to 15μM on day4 R05 exp222	2.53

Global Fraction of Cell Lines Where Essential: 703/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	28/28
bone	26/26
breast	32/33
central nervous system	54/56
cervix	3/4
colorectal	15/17
esophagus	10/13
fibroblast	1/1
gastric	15/16
kidney	18/21
liver	20/20
lung	74/75
lymphocyte	16/16
ovary	25/26
pancreas	20/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	9/9
thyroid	1/2
upper aerodigestive	19/22
urinary tract	26/29
uterus	5/5

Expression Distribution

post-spliceosomal complex
first spliceosomal transesterification activity
generation of catalytic spliceosome for second transesterification step
spliceosomal conformational changes to generate catalytic conformation
mRNA 3-splice site recognition
post-mRNA release spliceosomal complex
U2-type catalytic step 1 spliceosome
Prp19 complex
mRNA splice site selection
spliceosomal complex assembly
transcription-coupled nucleotide-excision repair
catalytic step 2 spliceosome
nucleotide-excision repair
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
ribonucleoprotein complex biogenesis
mRNA processing
DNA repair
mRNA metabolic process
DNA metabolic process
cellular response to DNA damage stimulus
cellular protein-containing complex assembly
RNA processing
RNA binding
protein-containing complex assembly
RNA metabolic process
cellular response to stress
protein-containing complex subunit organization
gene expression