ISY1 [The Human Chemical-Genetic Interaction Map Project]

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======= ISY1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ISY1
  * **<color #00a2e8>Official Name</color>**: ISY1 splicing factor homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57461|57461]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULR0|Q9ULR0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ISY1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ISY1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612764|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in pre-mRNA splicing. {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Isy1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-spliceosomal complex|
|first spliceosomal transesterification activity|
|generation of catalytic spliceosome for second transesterification step|
|spliceosomal conformational changes to generate catalytic conformation|
|mRNA 3-splice site recognition|
|post-mRNA release spliceosomal complex|
|U2-type catalytic step 1 spliceosome|
|Prp19 complex|
|mRNA splice site selection|
|spliceosomal complex assembly|
|transcription-coupled nucleotide-excision repair|
|catalytic step 2 spliceosome|
|nucleotide-excision repair|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|DNA repair|
|mRNA metabolic process|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|RNA processing|
|RNA binding|
|protein-containing complex assembly|
|RNA metabolic process|
|cellular response to stress|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.73|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.71|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.71|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.72|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.73|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.75|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.75|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.84|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.85|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.87|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.89|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.94|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.95|
|[[:results:exp331|A-769662 20μM R07 exp331]]|2.1|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|2.1|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|2.23|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|2.27|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.32|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.38|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.501|
|[[:human genes:p:psmb2|PSMB2]]|0.463|
|[[:human genes:s:slc6a17|SLC6A17]]|0.462|
|[[:human genes:t:tceb3c|TCEB3C]]|0.43|
|[[:human genes:r:rps7|RPS7]]|0.429|
|[[:human genes:p:psmd3|PSMD3]]|0.426|
|[[:human genes:p:paf1|PAF1]]|0.424|
|[[:human genes:n:ncl|NCL]]|0.41|
|[[:human genes:l:lrr1|LRR1]]|0.409|
|[[:human genes:r:rrp7a|RRP7A]]|0.409|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.408|
|[[:human genes:s:sf3a3|SF3A3]]|0.402|
|[[:human genes:e:eif4a3|EIF4A3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 703/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|54/56|
|cervix|3/4|
|colorectal|15/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|18/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|20/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|1/2|
|upper aerodigestive|19/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1656
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ISY1 Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>