Cidofovir 10μM R07 exp345
Mechanism of Action
Acyclic nucleoside phosphonate, inhibits DNA polymerase
- Class / Subclass 1: Infectious Disease / Antiviral
- Class / Subclass 2: Metabolism / Antimetabolite
- Class / Subclass 3: DNA Damage, Repair and Replication / Replication Inhibitor
Technical Notes
Compound References
- PubChem Name: Cidofovir
- Synonyms: GS 0504; HPMPC; (S)-HPMPC
- CAS #: 113852-37-2
- PubChem CID: 60613
- IUPAC: [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid
- INCHI Name: InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
- INCHI Key: VWFCHDSQECPREK-LURJTMIESA-N
- Molecular Weight: 279.19
- Canonical SMILES: C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O
- Isomeric SMILES: C1=CN(C(=O)N=C1N)C[C@@H](CO)OCP(=O)(O)O
- Molecular Formula: C8H14N3O6P
Compound Supplier
- Supplier Name: Med Chem Express
- Catalog #: HY-17438
- Lot #: 10174
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C8H14N3O6P 280.0693; found 280.0678
Dose Response Curve
- Platform ID: Cidofovir
- Min: -9.0750; Max: 18.2460
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 07
- Dose: 10µM
- Days of incubation: 8
- Doublings: 6.8
- Numbers of reads: 17802170
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Cidofovir 10μM R07 exp345
