ZNF622

Entrez Summary: N/A
UniProt Summary: May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Benzoate 10000μM R08 exp455	1.7
GSK461364A 0.005μM R03 exp125	1.71
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.81
UM0131023 0.05μM R05 exp248	1.92
HMS-I2 10μM R06 exp288	1.95
GSK591 2.6μM R03 exp128	2.06
Citral 50μM R06 exp274	2.07
Cidofovir 10μM R07 exp345	2.15
ML-792 0.2μM R08 exp505	2.21
BI-2536 0.0042μM R03 exp95	2.41

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zf-C2H2 jaz
zf-C2H2 2

intrinsic apoptotic signaling pathway in response to oxidative stress
cell death in response to oxidative stress
preribosome, large subunit precursor
cytosolic large ribosomal subunit
ribosomal large subunit biogenesis
positive regulation of JNK cascade
intrinsic apoptotic signaling pathway
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
regulation of JNK cascade
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
cellular response to oxidative stress
apoptotic signaling pathway
ribosome biogenesis
response to oxidative stress
ribonucleoprotein complex biogenesis
positive regulation of MAPK cascade
positive regulation of kinase activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of transferase activity
positive regulation of cell death
regulation of cellular response to stress
regulation of MAPK cascade
zinc ion binding
nucleolus
regulation of kinase activity
apoptotic process
regulation of transferase activity
Golgi apparatus
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
programmed cell death
positive regulation of phosphorylation
cell death
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of protein modification process
RNA binding