RPL15

Entrez Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tanespimycin 14μM R08 exp527	-1.8
Etoposide 0.3μM R05 exp199	-1.7
Momordin-Ic 10μM R08 exp506	1.78
Dimethyloxaloylglycine 11μM R07 exp314	1.97
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.71

Global Fraction of Cell Lines Where Essential: 610/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	21/28
blood	26/28
bone	22/26
breast	22/33
central nervous system	50/56
cervix	3/4
colorectal	13/17
esophagus	13/13
fibroblast	0/1
gastric	13/16
kidney	20/21
liver	17/20
lung	58/75
lymphocyte	14/16
ovary	21/26
pancreas	19/24
peripheral nervous system	13/16
plasma cell	15/15
prostate	1/1
skin	22/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	21/29
uterus	3/5

Expression Distribution

ribosome
cytosolic large ribosomal subunit
cytoplasmic translation
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
viral transcription
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
viral gene expression
protein localization to endoplasmic reticulum
translational initiation
protein targeting to membrane
structural constituent of ribosome
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
RNA catabolic process
establishment of protein localization to membrane
cadherin binding
protein targeting
nucleobase-containing compound catabolic process
translation
peptide biosynthetic process
establishment of protein localization to organelle
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
protein localization to membrane
organic cyclic compound catabolic process
amide biosynthetic process
peptide metabolic process
mRNA metabolic process
viral process
protein localization to organelle
symbiotic process
cellular amide metabolic process
interspecies interaction between organisms
cellular macromolecule catabolic process
intracellular protein transport
macromolecule catabolic process