KIAA0947

Gene Information

Official Symbol: ICE1
Official Name: interactor of little elongation complex ELL subunit 1
Aliases and Previous Symbols: N/A
Entrez ID: 23379
UniProt: Q9Y2F5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.73
Nifuroxazide 1μM R01 exp51	1.76
Taxol 0.002μM R01 exp54	1.77
CCT251545 20μM R07 exp326	1.83
Dexamethasone 0.006μM R07 exp351	1.85
2-Methoxyestradiol 0.2μM R01 exp40	1.9
PF-06409577 20μM R07 exp389	1.91
Dihydrosphingosine 8μM R08 exp476	2.06
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.26
UNC1999 2μM R03 exp155	2.31
THZ531 0.11μM R07 exp409	2.77

Gene	Correlation
RPL35	0.518
CHD4	0.498
SF3A3	0.489
PSMB4	0.482
GOLGA6L1	0.477
TCEB3CL2	0.474
TCEB3C	0.473
VASN	0.464
C1QTNF9B	0.459
PSMD2	0.453
INTS5	0.449
NOL10	0.449
WDR75	0.448
RPL6	0.448
TCEB3CL	0.445
BRD2	0.444
TICRR	0.444
TWISTNB	0.439
PSMA7	0.436
RPS9	0.434
PRIM1	0.434
C14orf93	0.431
CGB2	0.431
HIST2H3A	0.429
COPE	0.429
EXOSC9	0.428
HIST2H3C	0.428
SF3B2	0.425
CTAGE4	0.424
PSMA6	0.422
RPS2	0.419
RPS5	0.417
POLE	0.416
RPL15	0.415
CACNA1A	0.413
NUP160	0.411
RPS3A	0.411
AKIRIN2	0.411
ORC1	0.409
PSMB2	0.409
RPS16	0.409
KCTD17	0.409
RPL30	0.408
POLA1	0.405
GOLGA6L3	0.404
RNF113A	0.403
NELFCD	0.403
RPS10	0.403
SLC6A17	0.403
NPIPB5	0.401
TSPY2	0.4
MFSD12	0.4

Global Fraction of Cell Lines Where Essential: 110/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	3/28
blood	3/28
bone	5/26
breast	8/33
central nervous system	5/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	5/21
liver	4/20
lung	10/75
lymphocyte	5/16
ovary	8/26
pancreas	2/24
peripheral nervous system	3/16
plasma cell	3/15
prostate	1/1
skin	3/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	2/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 1600
Expression level (log2 read counts): 7.43

Expression Distribution

histone locus body
snRNA transcription by RNA polymerase III
positive regulation of transcription by RNA polymerase III
regulation of transcription by RNA polymerase III
transcriptionally active chromatin
transcription elongation factor complex
transcription by RNA polymerase III
Cajal body
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
positive regulation of intracellular protein transport
positive regulation of intracellular transport
regulation of intracellular protein transport
positive regulation of protein complex assembly
nuclear body
positive regulation of cellular protein localization
regulation of intracellular transport
positive regulation of protein transport
regulation of protein complex assembly
positive regulation of establishment of protein localization
transcription by RNA polymerase II
positive regulation of cellular component biogenesis
regulation of cellular protein localization
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
protein homodimerization activity
regulation of cellular localization
regulation of cellular component biogenesis
positive regulation of transport
regulation of protein localization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of cellular component organization
organic cyclic compound biosynthetic process