Taxol 0.002μM R01 exp54
Mechanism of Action
Inhibits microtubule depolymerisation, blocks metaphase to anaphase transition
- Class / Subclass 1: Cell Cycle / Microtubule Poison
- Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor
Technical Notes
Compound References
- PubChem Name: Paclitaxel
- Synonyms: Taxol
- CAS #: 33069-62-4
- PubChem CID: 36314
- IUPAC: [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
- INCHI Name: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
- INCHI Key: RCINICONZNJXQF-MZXODVADSA-N
- Molecular Weight: 853.9
- Canonical SMILES: CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
- Isomeric SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
- Molecular Formula: C47H51NO14
Compound Supplier
- Supplier Name: LC Laboratories
- Catalog #: P-9600
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C47H51NO14 854.33823; found 854.33694
Dose Response Curve
- Platform ID: Taxol
- Min: 2.6702; Max: 74.3395
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 0.0003 |
| IC30 | 0.0010 |
| IC40 | 0.0025 |
| IC50 | 0.0058 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 01
- Dose: 2nM
- Days of incubation: 8
- Doublings: 7.1
- Numbers of reads: 15697968
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 4/0 | Scores |
Taxol 0.002μM R01 exp54
Taxol 0.002μM R01 exp54 vs UM131593 0.1μM R01 exp58
Taxol 0.002μM R01 exp54 vs Vinblastine 0.002μM R01 exp60
Docetaxel 0.002μM R01 exp45 vs Taxol 0.002μM R01 exp54
HMS-I1 1μM R01 exp46 vs Taxol 0.002μM R01 exp54
NFN1 0.1μM R01 exp49 vs Taxol 0.002μM R01 exp54
BI-6727 0.001μM R01 exp42 vs Taxol 0.002μM R01 exp54
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 vs Taxol 0.002μM R01 exp54
BI-2536 0.001μM R01 exp41 vs Taxol 0.002μM R01 exp54
Docetaxel 0.001 to 0.002μM on day4 R04 exp159 vs Taxol 0.002μM R01 exp54
