YRDC

Entrez Summary: N/A
UniProt Summary: May regulate the activity of some transporters. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
I-BRD9 4μM R07 exp365	-3.27
YM155 0.0002μM R01 exp61	-2.59
Cannabidiol 20μM R08 exp466	-2.47
S-trityl-L-cysteine 0.5μM R05 exp243	-2.47
SNS-032 15μM R08 exp443	-2.29
Rapamycin 2μM R07 exp306	-2.22
Taxol 0.002μM R01 exp54	-2.22
QNZ 0.01μM R08 exp439	-2.17
Amiloride 100μM R08 exp447	-2.02
NMS-873 0.07μM R07 exp380	-1.95
CAY10603 0.55μM R08 exp467	-1.93
A-769662 20μM R07 exp331	-1.92
Tanespimycin 14μM R08 exp527	-1.83
Methotrexate 0.01μM R08 exp501	-1.8
Aphidicolin 0.4μM R08 exp440	-1.78
iCRT14 30μM R08 exp492	-1.76
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.76
Vinblastine 0.002μM R01 exp60	-1.75
SB743921 0.001μM R05 exp244	-1.72
FBS-Wisent 0.1 R07 exp426	-1.72
Torin1 0.08μM R02 exp82	1.72

Global Fraction of Cell Lines Where Essential: 665/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	27/28
blood	28/28
bone	23/26
breast	32/33
central nervous system	33/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	0/1
gastric	16/16
kidney	20/21
liver	17/20
lung	67/75
lymphocyte	16/16
ovary	22/26
pancreas	23/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	0/1
skin	24/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	15/22
urinary tract	25/29
uterus	4/5

Expression Distribution

nucleotidyltransferase activity
regulation of translational fidelity
tRNA binding
double-stranded RNA binding
negative regulation of transport
mitochondrion
regulation of transport
membrane