YRDC [The Human Chemical-Genetic Interaction Map Project]

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======= YRDC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YRDC
  * **<color #00a2e8>Official Name</color>**: yrdC N6-threonylcarbamoyltransferase domain containing
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79693|79693]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86U90|Q86U90]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YRDC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YRDC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612276|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May regulate the activity of some transporters. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sua5 yciO yrdC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleotidyltransferase activity|
|regulation of translational fidelity|
|tRNA binding|
|double-stranded RNA binding|
|negative regulation of transport|
|mitochondrion|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-3.27|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.59|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.47|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.47|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.29|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.22|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.22|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.17|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.02|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.95|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.93|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.92|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.83|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.8|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.78|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.76|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.76|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.75|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.72|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.72|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.438|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 665/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|23/26|
|breast|32/33|
|central nervous system|33/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|0/1|
|gastric|16/16|
|kidney|20/21|
|liver|17/20|
|lung|67/75|
|lymphocyte|16/16|
|ovary|22/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|0/1|
|skin|24/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|15/22|
|urinary tract|25/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1147
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YRDC Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>