A-769662 20μM R07 exp331
Mechanism of Action
Activates AMP-activated protein kinase (AMPK), allosteric
- Class / Subclass 1: Signal Transduction / Kinase Activator
Technical Notes
Compound References
- PubChem Name: 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
- Synonyms: N/A
- CAS #: 844499-71-4
- PubChem CID: 54708532
- IUPAC: 4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile
- INCHI Name: InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25)
- INCHI Key: CTESJDQKVOEUOY-UHFFFAOYSA-N
- Molecular Weight: 360.4
- Canonical SMILES: C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O
- Isomeric SMILES: N/A
- Molecular Formula: C20H12N2O3S
Compound Supplier
- Supplier Name: Ark Pharm Inc.
- Catalog #: AK117003
- Lot #: YF0167194-170704001
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C20H12N2O3S 361.06414; found 361.06413
Dose Response Curve
- Platform ID: A-769662
- Min: -18.4953; Max: 18.9840
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 07
- Dose: 20µM
- Days of incubation: 8
- Doublings: 7.2
- Numbers of reads: 20919857
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
A-769662 20μM R07 exp331
