GDF9

Entrez Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Reduced expression of this gene may be associated with polycystic ovary syndrome and mutations in this gene may be more common in mothers of dizygotic twins. [provided by RefSeq, Jul 2016].
UniProt Summary: Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. {ECO:0000269|PubMed:12050262, ECO:0000269|PubMed:19366876, ECO:0000269|PubMed:20660033, ECO:0000269|PubMed:21632818, ECO:0000269|PubMed:21829661}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I1 10μM R06 exp256	-2.14
NN-Diethyl-meta-toluamide 500μM R08 exp438	-2.09
A-769662 20μM R07 exp331	-1.89
BML-284 0.09μM R08 exp460	1.74
Cisplatin 0.35μM R06 exp273	1.78
Momordin-Ic 10μM R08 exp506	1.91
GSK-LSD1 10μM R03 exp123	1.99
AICAR 240μM R03 exp116	2.25

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of progesterone secretion
oocyte growth
regulation of female gonad development
regulation of steroid hormone secretion
regulation of gonad development
oocyte development
transforming growth factor beta receptor binding
oocyte differentiation
regulation of endocrine process
positive regulation of pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
regulation of pathway-restricted SMAD protein phosphorylation
oogenesis
developmental cell growth
cell growth
BMP signaling pathway
regulation of response to drug
transforming growth factor beta receptor signaling pathway
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
response to BMP
cellular response to BMP stimulus
regulation of lipid transport
female gamete generation
regulation of lipid localization
cellular response to transforming growth factor beta stimulus
regulation of reproductive process
response to transforming growth factor beta
growth factor activity
cytokine activity
negative regulation of cell growth
transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of growth
germ cell development
regulation of hormone secretion
cellular process involved in reproduction in multicellular organism
developmental growth
growth
regulation of cell growth
cellular response to growth factor stimulus