BML-284 0.09μM R08 exp460

Wnt agonist, GSK3-‘_ dependent, activates ‘_-catenin/TCF-dependent transcription

PubChem Name: Wnt Agonist
Synonyms: N/A
CAS #: 853220-52-7
PubChem CID: 11210285
IUPAC: 4-N-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine
INCHI Name: InChI=1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)
INCHI Key: FABQUVYDAXWUQP-UHFFFAOYSA-N
Molecular Weight: 350.4
Canonical SMILES: COC1=CC=CC(=C1)C2=CC(=NC(=N2)N)NCC3=CC4=C(C=C3)OCO4
Isomeric SMILES: N/A
Molecular Formula: C19H18N4O3

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
63/37	Scores	View	View	View	View	View

Screen	Correlation	Plot
Mdivi-1 15μM R05 exp217	0.207	View
UM131593 0.2μM R03 exp106	0.172	View
UMK57 1μM R01 exp59	0.172	View
Colchicine 0.009μM R05 exp215	0.136	View
Demecolcine 0.03μM R05 exp228	0.121	View
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	0.121	View
Vincristine 0.0005μM R04 exp190	0.116	View
Taxol 0.004μM R03 exp103	0.109	View
BVD-523 15μM R02 exp67	0.107	View
Quercetin 20μM R08 exp517	0.106	View
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	0.104	View
Vinblastine 0.002μM R01 exp60	0.094	View
Epothilone-B 0.0015μM R05 exp231	0.076	View
S-trityl-L-cysteine 0.5μM R05 exp243	0.075	View
Milciclib 2μM R08 exp502	0.067	View
Genistein 15μM R07 exp360	0.063	View
UMK57 0.6μM R03 exp107	0.062	View
Hydroxyurea 100μM R07 exp329	0.062	View
Sulforaphane 9μM R08 exp526 no dilution day6	0.061	View
HMS-I1 1μM R01 exp46	0.058	View
LLY-283 2.6μM R06 exp290	0.057	View
GSK626616 14μM R08 exp485	0.056	View
Dorsomorphin 5μM R07 exp357	0.055	View
Sulforaphane 9μM R08 exp525	0.055	View
JQ1 0.8μM R08 exp435	0.055	View
CoCl2 18μM R07 exp346	0.054	View
Docetaxel 0.002μM R01 exp45	0.053	View
Diepoxybutane 3μM R07 exp354	0.053	View
LY2090314 0.003μM R08 exp500 no dilution day6	0.053	View
Docosahexaenoic-acid 50μM R07 exp356	0.051	View
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	0.137	View
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	0.095	View
2-Methoxyestradiol 0.55μM R07 exp310	0.089	View
BI-6727 0.0125μM R03 exp97	0.071	View
3-Bromopyruvate 7μM R04 exp175	0.064	View
5-Fluorouracil 20μM R00 exp2	0.051	View

GO Term	Fold Change	Genes
kinetochore microtubule	95.22	KIF18A,KNTC1,ZWILCH
chromosome localization	30.07	KIF18A,MAPRE1,DLGAP5,KIFC1,KATNB1
regulation of sister chromatid segregation	27.74	DLGAP5,TRIP13,KNTC1,TACC3,ZWILCH
mitotic sister chromatid segregation	25.02	KIF18A,MAPRE1,DLGAP5,KIFC1,KNTC1,KATNB1
sister chromatid segregation	24.31	KIF18A,MAPRE1,DLGAP5,KIFC1,KNTC1,KATNB1
spindle pole	23.53	ASPM,MAPRE1,YPEL5,DLGAP5,KNTC1,TACC3,KATNB1
mitotic spindle	22.47	KIF18A,ASPM,MAPRE1,YPEL5,DLGAP5,KIFC1,TACC3
mitotic nuclear division	20.90	KIF18A,MAPRE1,DLGAP5,KIFC1,KNTC1,KATNB1
nuclear chromosome segregation	20.78	KIF18A,ASPM,MAPRE1,DLGAP5,KIFC1,TRIP13,KNTC1,KATNB1
chromosome segregation	15.68	KIF18A,ASPM,MAPRE1,DLGAP5,KIFC1,TRIP13,ESCO2,KNTC1,KATNB1
spindle	15.14	KIF18A,ASPM,MAPRE1,YPEL5,DLGAP5,KIF15,KIFC1,KNTC1,TACC3,KATNB1,ZWILCH
nuclear division	15.04	KIF18A,ASPM,MAPRE1,DLGAP5,KIFC1,TRIP13,KNTC1,KATNB1
organelle fission	13.89	KIF18A,ASPM,MAPRE1,DLGAP5,KIFC1,TRIP13,KNTC1,KATNB1
chromosome organization	11.69	KIF18A,MAPRE1,PDS5B,DLGAP5,KIFC1,TRIP13,ESCO2,KNTC1,KATNB1
microtubule	10.53	KIF18A,ASPM,MAPRE1,KIF15,KIFC1,KNTC1,KATNB1,ZWILCH
mitotic cell cycle process	9.97	KIF18A,MAPRE1,DLGAP5,KIFC1,TRIP13,KNTC1,TACC3,KATNB1,ZWILCH
mitotic cell cycle	9.52	KIF18A,MAPRE1,DLGAP5,KIF15,KIFC1,TRIP13,KNTC1,TACC3,KATNB1,ZWILCH
cell division	9.03	ASPM,MAPRE1,PDS5B,KIFC1,KNTC1,TACC3,KATNB1,ZWILCH
cell cycle process	7.86	KIF18A,ASPM,MAPRE1,PDS5B,DLGAP5,KIFC1,TRIP13,ESCO2,KNTC1,TACC3,KATNB1,ZWILCH

GO Term	Fold Change	Genes
mitotic cell cycle process	8.56	TP53,CCNF,KHDRBS1,KIF18B,NDE1,LCMT1,NUMA1,MBTPS1
mitotic cell cycle	7.36	TP53,CCNF,KHDRBS1,KIF18B,NDE1,LCMT1,NUMA1,MBTPS1