YPEL5

Gene Information

Official Symbol: YPEL5
Official Name: yippee like 5
Aliases and Previous Symbols: N/A
Entrez ID: 51646
UniProt: P62699
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Palbociclib 1μM R07 exp382	-4.95
Mdivi-1 15μM R05 exp217	-4.8
Milciclib 2μM R08 exp502	-4.39
BVD-523 15μM R02 exp67	-3.79
Fluvastatin 2.2μM R06 exp282	-3.63
Cerivastatin 0.15μM R05 exp226	-3.57
UMK57 1μM R01 exp59	-3.46
BML-284 0.09μM R08 exp460	-3.38
FK-506 30μM R07 exp359	-3.36
JQ1 0.8μM R08 exp435	-3.26
Olaparib 4μM R08 exp512	-2.99
5-Fluorouracil 2μM R00 exp1	-2.85
Thimerosal 0.85μM R08 exp529	-2.8
3-Bromopyruvate 7μM R04 exp175	-2.66
GSK591 2.6μM R03 exp128	-2.55
UM0129480 7μM R02 exp85	-2.54
Rotenone 2μM R00 exp33	-2.53
Cryptotanshinone 12μM R05 exp227	-2.48
Brefeldin A 0.02μM R00 exp8	-2.41
2-Deoxy-D-glucose 800μM R05 exp214	-2.4
LLY-283 2.6μM R06 exp290	-2.34
Dorsomorphin 5μM R07 exp357	-2.25
Oligomycin-A 2μM R00 exp25	-2.22
iCRT14 30μM R08 exp492	-2.21
UM131593 0.2μM R03 exp106	-2.19
WYE-354 6μM R02 exp90	-2.17
42°C R08 exp539	-2.16
Dinaciclib 0.007μM R07 exp355	-2.12
Apcin 25μM plus proTAME 2μM R04 exp177	-2.09
BI-6727 0.0125μM R03 exp97	-2.08
CB-839 10μM R05 exp224	-2.01
CoCl2 18μM R07 exp346	-2.01
Trimetrexate 0.03μM R08 exp535	-1.99
Diepoxybutane 3μM R07 exp354	-1.97
ML-792 0.2μM R08 exp505	-1.96
Quercetin 20μM R08 exp517	-1.95
Vinblastine 0.002μM R01 exp60	-1.95
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.9
Monensin 0.3μM R08 exp507	-1.89
Bortezomib 0.05μM R00 exp7	-1.87
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.85
ONC212 0.15μM R08 exp513	-1.8
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.78
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.76
Artemisinin 50μM R08 exp450	-1.76
Benzoate 20000μM R08 exp456	-1.76
IU1-C 25μM R04 exp183	-1.76
Oligomycin-A 20μM R00 exp26	-1.76
BI-D1870 3.15μM R02 exp66	-1.71
DABN 20μM R00 exp17	-1.71
LJH685 5μM R02 exp73	1.7
PT-1 25μM R07 exp392	1.78
Ibrutinib 1μM R07 exp372	1.91
Pomalidomide 20μM R07 exp391	1.93
EPZ-5676 30μM R05 exp233	1.97
Azithromycin 100μM R08 exp452	2.16
Thapsigargin 0.005μM R07 exp407	2.19
Tubacin 1.6μM R07 exp416	2.28
Pyridostatin 4μM R05 exp240	2.34
Tozasertib 0.1μM R07 exp414	2.4
Rapamycin 2μM plus FK-506 5μM R07 exp308	2.52
Hippuristanol 0.12μM R08 exp488	2.54
MS023 2μM R03 exp134	2.57
Actinomycin-D 0.001μM R00 exp3	2.83
AICAR 240μM R05 exp211	2.91
Clomiphene 4.4μM R02 exp68	2.94
Arsenate 40μM R06 exp264	3.04
Hippuristanol 0.12μM R08 exp489 no dilution day6	3.13
Dimethyloxaloylglycine 100μM R05 exp229	3.16
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	3.37
Dexamethasone 0.006μM R07 exp351	3.48
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	3.64
Rapamycin 0.001μM R08 exp429	3.85
AICAR 240μM R03 exp116	5.57
Rapamycin 1μM R00 exp29	5.81
Rapamycin 2μM R07 exp306	6.34
Rapamycin 10μM R00 exp30	6.73

Gene	Correlation
WDR26	0.822
UBE2H	0.792
MAEA	0.683
GID8	0.645
MEMO1	0.587
GSK3B	0.515
FKBP1A	0.493
GSKIP	0.489
CNOT8	0.48
OTUB1	0.479
CDK8	0.454
ANP32A	0.451
KDM6A	0.438
POU2AF1	0.426
RMND5A	0.424
CNOT2	0.419
DNTTIP1	0.414
FAM122A	0.414
GLYR1	0.412
UTY	0.412
TSC2	0.404

Global Fraction of Cell Lines Where Essential: 228/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	16/28
blood	5/28
bone	8/26
breast	16/33
central nervous system	15/56
cervix	0/4
colorectal	4/17
esophagus	1/13
fibroblast	1/1
gastric	7/16
kidney	3/21
liver	8/20
lung	22/75
lymphocyte	2/16
ovary	9/26
pancreas	14/24
peripheral nervous system	6/16
plasma cell	5/15
prostate	1/1
skin	9/24
soft tissue	1/9
thyroid	1/2
upper aerodigestive	7/22
urinary tract	7/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 11110
Expression level (log2 read counts): 3.18

Expression Distribution

mitotic spindle pole
tertiary granule lumen
ubiquitin ligase complex
ficolin-1-rich granule lumen
midbody
neutrophil degranulation
centrosome
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
cell population proliferation
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
leukocyte mediated immunity
exocytosis
leukocyte activation
secretion by cell
export from cell
cell activation
immune effector process
secretion
immune response
extracellular region
vesicle-mediated transport