Monensin 0.3μM R08 exp507
Mechanism of Action
Polyether antibiotic, binds monovalent cations, Na+/H+ antiporter, blocks Golgi transport
- Class / Subclass 1: Infectious Disease / Antibiotic
- Class / Subclass 2: Organelle Function / Membrane Ionophore
Technical Notes
Compound References
- PubChem Name: Monensin sodium
- Synonyms: Monensin A sodium salt
- CAS #: 22373-78-0
- PubChem CID: 23667299
- IUPAC: sodium;(2S,3R,4S)-4-[(2S,5R,7S,8R,9S)-2-[(2R,5S)-5-ethyl-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]oxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoate
- INCHI Name: InChI=1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35+,36-;/m0./s1
- INCHI Key: XOIQMTLWECTKJL-FBZUZRIGSA-M
- Molecular Weight: 692.9
- Canonical SMILES: CCC1(CCC(O1)C2(CCC3(O2)CC(C(C(O3)C(C)C(C(C)C(=O)[O-])OC)C)O)C)C4C(CC(O4)C5C(CC(C(O5)(CO)O)C)C)C.[Na+]
- Isomeric SMILES: CC[C@]1(CC[C@@H](O1)[C@@]2(CC[C@@]3(O2)C[C@@H]([C@H]([C@H](O3)[C@@H](C)[C@H]([C@H](C)C(=O)[O-])OC)C)O)C)[C@H]4[C@H](C[C@@H](O4)[C@@H]5[C@H](C[C@H]([C@@](O5)(CO)O)C)C)C.[Na+]
- Molecular Formula: C36H61NaO11
Compound Supplier
- Supplier Name: Med Chem Express
- Catalog #: HY-N0150
- Lot #: 28765
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+Na)+ Calcd for C36H62O11 693.41843; found 693.41958
Dose Response Curve
- Platform ID: Monensin
- Min: -4.4012; Max: 96.4158
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 0.0433 |
| IC30 | 0.0965 |
| IC40 | 0.1929 |
| IC50 | 0.3731 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 08
- Dose: 300nM
- Days of incubation: 8
- Doublings: 0.9
- Numbers of reads: 16398044
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 19/5 | Scores |
Monensin 0.3μM R08 exp507
Monensin 0.3μM R08 exp507 vs Vemurafenib 6.6μM R08 exp434
Monensin 0.3μM R08 exp507 vs PU-H71 1μM R08 exp515
Monensin 0.3μM R08 exp507 vs WYE-354 6μM R02 exp90
Monensin 0.3μM R08 exp507 vs Tanespimycin 14μM R08 exp527
Monensin 0.3μM R08 exp507 vs Vemurafenib 6.6μM R02 exp89
Monensin 0.3μM R08 exp507 vs Q15 1 to 2μM on day4 R04 exp164
Monensin 0.3μM R08 exp507 vs Nicotine 3000μM R08 exp510
Ammonium tetrathiomolybdate 10μM R08 exp448 vs Monensin 0.3μM R08 exp507
JQ1 0.8μM R08 exp435 vs Monensin 0.3μM R08 exp507
BS-181 20μM R08 exp461 vs Monensin 0.3μM R08 exp507
Clomiphene 4.4μM R02 exp68 vs Monensin 0.3μM R08 exp507
CFI-400945 25μM R08 exp469 vs Monensin 0.3μM R08 exp507
BH1 1μM R04 exp169 vs Monensin 0.3μM R08 exp507
