TMED10

Gene Information

Official Symbol: TMED10
Official Name: transmembrane p24 trafficking protein 10
Aliases and Previous Symbols: N/A
Entrez ID: 10972
UniProt: P49755
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus. {ECO:0000250, ECO:0000269|PubMed:10052452, ECO:0000269|PubMed:11726511, ECO:0000269|PubMed:16641999, ECO:0000269|PubMed:17288597, ECO:0000269|PubMed:19296914, ECO:0000269|PubMed:20427317, ECO:0000269|PubMed:21219331}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Golgicide-A 4μM R03 exp122	-3
Cincreasin 100μM R08 exp473	-2.59
Bortezomib 0.005μM R00 exp6	-2.34
Lead acetate 2000μM R08 exp498 no dilution day6	-2.17
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.16
Ethanol 0.01 R05 exp234	-2.13
Rapamycin 10μM R00 exp30	-2.13
2-Methoxyestradiol 0.55μM R07 exp310	-2.04
UM0011500 5μM R05 exp245	-2.01
Beta-Estradiol 0.55μM R07 exp425	-1.97
Adefovir 20μM R07 exp332	-1.91
CB-5083 0.4μM R08 exp468	-1.85
Dynasore 10μM R04 exp180	-1.82
B02 10μM R08 exp453	-1.8
Tunicamycin 0.04μM R07 exp418	-1.8
Calcium Ionophore 0.4μM R07 exp342	-1.79
IL-3 9ng/ml R08 exp493	-1.75
All-trans-Retinoic-Acid 40μM R07 exp334	-1.71
Demecolcine 0.03μM R05 exp228	-1.7
AICAR 240μM R05 exp211	1.7
Clomiphene 4.4μM R02 exp68	1.76
BI-6727 0.0125μM R03 exp97	1.79
DABN racemic mixture R03 exp93	1.88
Etoposide 1μM R00 exp19	1.9
Tanespimycin 14μM R08 exp527	1.95
Doxorubicin 0.02μM R08 exp478	2.02
Rotenone 20μM R00 exp34	2.04
Arsenate 40μM R06 exp264	2.07
CI-1040 9.5μM R08 exp472	2.14
Pyridostatin 4μM R05 exp240	2.14
Benzoate 20000μM R08 exp456	2.18
5-Fluorouracil 20μM R00 exp2	2.26
Etoposide 0.1μM R05 exp198	2.27
TRAIL 5ng/ml R00 exp35	2.27
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.66
Monensin 0.3μM R08 exp507	2.69
LLY-283 2.6μM R06 exp290	2.92
42°C R08 exp539	3.4

Gene	Correlation
TMED2	0.611
DNAJC3	0.556
ALG5	0.55
MANF	0.524
ALG6	0.514
UBE2G2	0.513
C1orf27	0.509
TMEM41B	0.509
SEC63	0.489
CCDC101	0.485
PMM2	0.478
UFC1	0.476
UBE2J1	0.476
UBA5	0.475
DPAGT1	0.47
ENY2	0.468
SEC62	0.466
RPTOR	0.463
DNAJB11	0.462
GTF3C4	0.461
KCMF1	0.458
ATP5J	0.455
ALG1	0.453
STT3A	0.451
USO1	0.451
GTF3C2	0.45
DERL1	0.45
GFPT1	0.45
CTDNEP1	0.449
LSMD1	0.446
UAP1	0.446
DPF2	0.446
RNMT	0.442
DOLK	0.44
PELO	0.439
UFSP2	0.437
SRP14	0.436
ATP5O	0.433
TIMM13	0.433
UFM1	0.432
UBE2K	0.432
FLI1	0.429
EIF4E	0.429
TRIAP1	0.428
MED16	0.426
MBTPS2	0.424
SEC61B	0.424
GMPPB	0.422
THG1L	0.42
VMP1	0.42
WDR24	0.412
CBFB	0.412
PPP2R3C	0.411
DERL2	0.411
RTCB	0.41
XPO6	0.408
TRMT10A	0.406
PLAA	0.403
AARS	0.401
ATP5A1	0.4

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	3/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4874
Expression level (log2 read counts): 7.6

Expression Distribution

COPI-coated vesicle budding
COPI coating of Golgi vesicle
Golgi transport vesicle coating
gamma-secretase complex
COPI-coated vesicle
zymogen granule membrane
trans-Golgi network transport vesicle
vesicle cargo loading
regulation of amyloid-beta formation
regulation of amyloid precursor protein catabolic process
COPII-coated ER to Golgi transport vesicle
ER to Golgi transport vesicle membrane
syntaxin binding
COPII vesicle coating
vesicle targeting, rough ER to cis-Golgi
cis-Golgi network
vesicle coating
COPII-coated vesicle budding
endoplasmic reticulum-Golgi intermediate compartment membrane
vesicle targeting, to, from or within Golgi
endoplasmic reticulum-Golgi intermediate compartment
Golgi vesicle budding
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
vesicle targeting
transport vesicle
vesicle budding from membrane
secretory granule membrane
melanosome
response to alkaloid
Golgi organization
establishment of vesicle localization
vesicle localization
endoplasmic reticulum to Golgi vesicle-mediated transport
protein-containing complex binding
kidney development
renal system development
vesicle organization
urogenital system development
establishment of organelle localization
Golgi vesicle transport