Ethanol 0.01 R05 exp234

Pleiotropic effects on membranes, ion channels, enzymes, receptors

Class / Subclass 1: Environmental Stresses / Solvent

Compound References

PubChem Name: Ethanol
Synonyms: N/A
CAS #: 64-17-5
PubChem CID: 702
IUPAC: ethanol
INCHI Name: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3
INCHI Key: LFQSCWFLJHTTHZ-UHFFFAOYSA-N
Molecular Weight: 46.07
Canonical SMILES: CCO
Isomeric SMILES: N/A
Molecular Formula: C2H6O

Compound Supplier

Supplier Name: Les Alcools de Commerce
Catalog #: P016EAAN
Lot #: N/A

Compound Characterization

Characterization data not available.

Dose Response Curve

Platform ID: EtOH
Min: -9.0156; Max: 4.5158

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 05
Dose: 1%
Days of incubation: 8
Doublings: 2.6
Numbers of reads: 19333524

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
27/78	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
BCL2	-3.40	<0.01
SEC31A	-3.11	<0.01
WSB1	-2.94	0.02
DERL2	-2.83	0.02
DNAJC3	-2.79	0.02
DERL1	-2.79	0.02
NGLY1	-2.78	0.02
DPAGT1	-2.75	0.02
RCE1	-2.62	0.02
SMG8	-2.61	0.02
RHOA	-2.61	0.02
FAM13B	-2.61	0.02
ALG9	-2.58	0.02
GNA13	-2.57	0.02
CSK	-2.54	0.06
FXR1	-2.54	0.02
SRSF5	-2.54	0.02
IRF4	-2.50	0.02
AIP	-2.49	0.02
SEC24C	-2.48	0.02
ATG9A	-2.47	0.02
BACH2	-2.47	0.04
SH3GL1	-2.46	0.04
USO1	-2.44	0.05
ZFP28	-2.42	0.03
ZC3H18	-2.40	0.13
STT3A	-2.40	0.08
IVL	-2.39	0.09
BCL2L1	-2.38	0.04
MBTPS1	-2.37	0.09
EIF3G	3.05	<0.01
BRMS1	3.08	<0.01
PDPK1	3.13	<0.01
CNOT2	3.15	<0.01
SRM	3.19	<0.01
ZNF207	3.44	<0.01
MCL1	3.46	<0.01
CD81	3.48	<0.01
PLAA	3.63	<0.01
AKT1	3.74	<0.01
HEXIM1	3.77	<0.01
CD19	3.86	<0.01
PRRC2C	4.11	<0.01
PTMA	4.14	<0.01
RHOH	4.15	<0.01
UBQLN1	4.38	<0.01
PIK3CD	4.39	<0.01
MLST8	4.40	<0.01
PDS5A	4.51	<0.01
ARRDC3	4.74	<0.01
PMAIP1	4.75	<0.01
VDAC2	4.84	<0.01
ARID4B	5.29	<0.01
MARCH5	5.56	<0.01
KMT2D	5.66	<0.01
BCL2L11	5.72	<0.01
RICTOR	6.11	<0.01
MAPKAP1	6.36	<0.01
DDX3X	7.12	<0.01
BAK1	8.00	<0.01

Screen	Correlation	Plot
MS023 2μM R03 exp134	0.126	View
Lead acetate 2000μM R08 exp498 no dilution day6	0.108	View
Hippuristanol 0.12μM R08 exp489 no dilution day6	0.104	View
Lead acetate 2000μM R08 exp497	0.1	View
Hippuristanol 0.12μM R08 exp488	0.1	View
ML-792 0.2μM R08 exp505	0.095	View
Olaparib 4μM R08 exp512	0.093	View
Thapsigargin 0.005μM R07 exp407	0.083	View
Sulforaphane 9μM R08 exp525	0.08	View
Nifuroxazide 5μM R03 exp102	0.077	View
Trimetrexate 0.03μM R08 exp535	0.074	View
Staurosporine 0.02μM R08 exp524	0.073	View
Latrunculin-B 10μM R07 exp374	0.069	View
LB-100 2μM R05 exp210	0.069	View
GSK626616 14μM R08 exp485	0.065	View
MLN-4924 0.2μM R00 exp21	0.065	View
MS023 7μM R03 exp135	0.065	View
JQ1 0.8μM R08 exp435	0.064	View
LY2090314 0.003μM R08 exp500 no dilution day6	0.061	View
THZ531 0.225μM R08 exp444	0.06	View
Sulforaphane 9μM R08 exp526 no dilution day6	0.059	View
iCRT14 30μM R08 exp492	0.058	View
Rapamycin 10μM R00 exp30	0.056	View
LY2090314 0.003μM R08 exp499	0.056	View
RO-3307 4.7μM R02 exp80	0.055	View
UM0129480 7μM R02 exp85	0.055	View
Pyridostatin 4μM R05 exp240	0.052	View
Benzoate 20000μM R08 exp456	0.097	View
AICAR 240μM R03 exp116	0.093	View
Benzoate 10000μM R08 exp455	0.082	View
Aphidicolin 0.4μM R08 exp440	0.08	View
Citral 50μM R06 exp274	0.079	View
Bortezomib 0.005μM R00 exp6	0.075	View
CB-5083 0.4μM R08 exp468	0.073	View
2-Deoxy-D-glucose 800μM R05 exp214	0.067	View
Erlotinib 10μM R05 exp216	0.062	View
Dinaciclib 0.007μM R07 exp355	0.059	View
AICAR 240μM R05 exp211	0.058	View
6-Thio-2-deoxyguanosine 2μM R06 exp259	0.057	View
EPZ-5676 30μM R05 exp233	0.056	View
Betulinic acid 10 to 15μM on day4 R05 exp222	0.055	View
Citral 75μM R06 exp275	0.054	View
B02 10μM R08 exp453	0.053	View
Azithromycin 100μM R08 exp452	0.052	View
Diepoxybutane 3μM R07 exp354	0.052	View
All-trans-Retinoic-Acid 40μM R07 exp334	0.051	View

GO Term	Fold Change	Genes
Bcl-2 family protein complex	245.48	BAK1,BCL2L11,PMAIP1,MCL1
TORC2 complex	207.13	MAPKAP1,RICTOR,MLST8
positive regulation of response to endoplasmic reticulum stress	63.12	BAK1,BCL2L11,PMAIP1,UBQLN1
apoptotic mitochondrial changes	59.18	BAK1,BCL2L11,VDAC2,PMAIP1,AKT1,MCL1
regulation of release of cytochrome c from mitochondria	50.21	BAK1,BCL2L11,PMAIP1,AKT1
regulation of mitochondrial membrane permeability	40.17	BAK1,BCL2L11,VDAC2,PMAIP1
extrinsic apoptotic signaling pathway	25.11	BAK1,DDX3X,BCL2L11,MCL1,PDPK1
regulation of intrinsic apoptotic signaling pathway	22.22	DDX3X,BCL2L11,VDAC2,PMAIP1,UBQLN1,AKT1,MCL1
positive regulation of cell growth	21.38	DDX3X,MAPKAP1,RICTOR,MLST8,AKT1,PLAA
mitochondrial outer membrane	16.01	BAK1,BCL2L11,MARCHF5,VDAC2,PMAIP1,MCL1
organelle outer membrane	14.10	BAK1,BCL2L11,MARCHF5,VDAC2,PMAIP1,MCL1
outer membrane	13.92	BAK1,BCL2L11,MARCHF5,VDAC2,PMAIP1,MCL1
positive regulation of growth	13.75	DDX3X,MAPKAP1,RICTOR,MLST8,AKT1,PLAA
kinase regulator activity	13.20	DDX3X,RICTOR,MLST8,RHOH,HEXIM1,AKT1
apoptotic signaling pathway	12.55	BAK1,DDX3X,BCL2L11,VDAC2,PMAIP1,MCL1,PDPK1
regulation of apoptotic signaling pathway	11.78	BAK1,DDX3X,BCL2L11,VDAC2,PMAIP1,UBQLN1,AKT1,MCL1
positive regulation of intracellular signal transduction	6.80	DDX3X,RICTOR,BCL2L11,PMAIP1,ARRDC3,MLST8,PIK3CD,HEXIM1,AKT1,CD81,MCL1,PDPK1
negative regulation of apoptotic process	6.36	BAK1,DDX3X,MAPKAP1,RICTOR,VDAC2,MLST8,PTMA,AKT1,MCL1,PDPK1
negative regulation of programmed cell death	6.18	BAK1,DDX3X,MAPKAP1,RICTOR,VDAC2,MLST8,PTMA,AKT1,MCL1,PDPK1

Ethanol 0.01 R05 exp234

Mechanism of Action

Technical Notes

Compound References

Compound Supplier

Compound Characterization

Dose Response Curve

Screen Summary

Screen Results