B02 10μM R08 exp453

Inhibits RAD51 recombinase, blocks homologous recombination

Class / Subclass 1: DNA Damage, Repair and Replication / Repair Protein Inhibitor

PubChem Name: RAD51 inhibitor B02
Synonyms: B02
CAS #: 1290541-46-6
PubChem CID: 5738263
IUPAC: 3-benzyl-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one
INCHI Name: InChI=1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+
INCHI Key: GEKDQXSPTHHANP-OUKQBFOZSA-N
Molecular Weight: 339.4
Canonical SMILES: C1=CC=C(C=C1)CN2C(=NC3=CC=CC=C3C2=O)C=CC4=CN=CC=C4
Isomeric SMILES: C1=CC=C(C=C1)CN2C(=NC3=CC=CC=C3C2=O)/C=C/C4=CN=CC=C4
Molecular Formula: C22H17N3O

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C22 H17 N3 O 340.14444; found 340.14521

Dose response curve not available.

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
11/0	Scores	View	View	View	View	View

Screen	Correlation	Plot
FTY720 3μM R08 exp483	0.077	View
Sulforaphane 9μM R08 exp525	0.076	View
Trametinib 10μM R02 exp83	0.071	View
Lead acetate 2000μM R08 exp498 no dilution day6	0.069	View
NN-Dimethylsphingosine 2.5μM R08 exp508	0.068	View
LJH685 50μM R08 exp433	0.066	View
Bisphenol F 50μM R08 exp457	0.066	View
FK-506 30μM R07 exp359	0.065	View
Benzoate 10000μM R08 exp455	0.064	View
Ibrutinib 10μM R08 exp442	0.063	View
Hydroxychloroquine 30μM R08 exp490	0.063	View
Thioridazine 5μM R08 exp530	0.062	View
EPZ-5676 30μM R05 exp233	0.059	View
Chloroquine 32μM R08 exp470	0.057	View
Sulforaphane 9μM R08 exp526 no dilution day6	0.057	View
Chlorpromazine 10μM R07 exp344	0.056	View
UM0011500 5μM R05 exp245	0.056	View
NN-Diethyl-meta-toluamide 500μM R08 exp438	0.056	View
BS-181 20μM R08 exp461	0.056	View
ZLN024 50μM R08 exp538	0.055	View
CAY10603 0.55μM R08 exp467	0.054	View
Ethanol 0.01 R05 exp234	0.053	View
CB-839 10μM R05 exp224	0.053	View
Nicotine 3000μM R08 exp510	0.052	View
IU1-47 25μM R04 exp182	0.051	View
Trimetrexate 0.03μM R08 exp535	0.051	View
Rucaparib 6.5μM R08 exp520	0.051	View