Thioridazine 5μM R08 exp530
Mechanism of Action
DRD2/4 selectivity, causes cardiac arrhythmia, also has antibiotic activity against M. tuberculosis
- Class / Subclass 1: Signal Transduction / GPCR Antagonist
Technical Notes
Compound References
- PubChem Name: Thioridazine hydrochloride
- Synonyms: N/A
- CAS #: 130-61-0
- PubChem CID: 66062
- IUPAC: 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine;hydrochloride
- INCHI Name: InChI=1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H
- INCHI Key: NZFNXWQNBYZDAQ-UHFFFAOYSA-N
- Molecular Weight: 407
- Canonical SMILES: CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC.Cl
- Isomeric SMILES: N/A
- Molecular Formula: C21H27ClN2S2
Compound Supplier
- Supplier Name: Sigma-Aldrich
- Catalog #: T9025
- Lot #: BCBV1701
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C21H26N2S2 371.16102; found 371.16222
Dose Response Curve
- Platform ID: Thioridazine
- Min: -11.3787; Max: 99.9166
| IC | Concentration (µM) |
|---|---|
| IC10 | 4.4700 |
| IC20 | 5.0190 |
| IC30 | 5.4210 |
| IC40 | 5.7740 |
| IC50 | 6.1180 |
| IC60 | 6.4830 |
| IC70 | 6.9050 |
| IC80 | 7.4580 |
| IC90 | 8.3730 |
Screen Summary
- Round: 08
- Dose: 5µM
- Days of incubation: 8
- Doublings: 6.2
- Numbers of reads: 15363012
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 16/1 | Scores |