BS-181 20μM R08 exp461

Inhibits CDK7, causes G1 arrest and apoptosis

PubChem Name: BS-181
Synonyms: N/A
CAS #: 1092443-52-1
PubChem CID: 49867929
IUPAC: 5-N-(6-aminohexyl)-7-N-benzyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-5,7-diamine
INCHI Name: InChI=1S/C22H32N6/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(19)28)24-13-9-4-3-8-12-23/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2,1-2H3,(H,24,27)
INCHI Key: DNYBIOICMDTDAP-UHFFFAOYSA-N
Molecular Weight: 380.5
Canonical SMILES: CC(C)C1=C2N=C(C=C(N2N=C1)NCC3=CC=CC=C3)NCCCCCCN
Isomeric SMILES: N/A
Molecular Formula: C22H32N6

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
20/1	Scores	View	View	View	View	View

Screen	Correlation	Plot
Chlorpromazine 10μM R07 exp344	0.133	View
Clomiphene 4.4μM R02 exp68	0.095	View
Thioridazine 5μM R08 exp530	0.091	View
Bafilomycin-A1 0.009μM R08 exp454	0.089	View
WYE-354 6μM R02 exp90	0.082	View
Nicotine 3000μM R08 exp510	0.082	View
FTY720 3μM R08 exp483	0.079	View
Cannabidiol 13μM R08 exp465	0.078	View
Cryptotanshinone 12μM R05 exp227	0.077	View
Lapatinib 5μM R01 exp47	0.076	View
ZLN024 50μM R08 exp538	0.074	View
CCT251545 20μM R07 exp326	0.074	View
Q15 1 to 2μM on day4 R04 exp164	0.072	View
Wiskostatin 3μM R07 exp422	0.072	View
L-74142 5μM R03 exp131	0.069	View
EPZ-5676 30μM R05 exp233	0.068	View
SB203580 25μM R03 exp149	0.063	View
Tubacin 1.6μM R07 exp416	0.062	View
MK2206 4μM R08 exp504	0.062	View
Monensin 0.3μM R08 exp507	0.061	View
CFI-400945 25μM R08 exp469	0.06	View
Bisphenol F 50μM R08 exp457	0.059	View
Cannabidiol 20μM R08 exp466	0.057	View
Ibrutinib 10μM R08 exp442	0.057	View
Vemurafenib 6.6μM R08 exp434	0.056	View
CB-839 10μM R05 exp224	0.055	View
IU1-47 25μM R04 exp182	0.053	View
∆-9-Tetrahydrocannabinol 30μM R08 exp445	0.052	View
Cyclosporin-A 3μM R07 exp348	0.052	View
NN-Dimethylsphingosine 2.5μM R08 exp508	0.052	View
Chloroquine 32μM R08 exp470	0.052	View
UNC1999 2μM R03 exp155	0.051	View
Bisphenol A 100μM R06 exp269	0.051	View
BH1 1μM R04 exp169	0.078	View
B02 10μM R08 exp453	0.056	View