L-74142 5μM R03 exp131 [The Human Chemical-Genetic Interaction Map Project]

DRD4 receptor antagonist

Class / Subclass 1: Signal Transduction / GPCR antagonist

Compound References

PubChem Name: 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-YL)isoxazole hydrochloride
Synonyms: N/A
CAS #: 874882-93-6
PubChem CID: 24744861
IUPAC: 5-(4-chlorophenyl)-4-methyl-3-[1-(2-phenylethyl)piperidin-4-yl]-1,2-oxazole;hydrochloride
INCHI Name: InChI=1S/C23H25ClN2O.ClH/c1-17-22(25-27-23(17)20-7-9-21(24)10-8-20)19-12-15-26(16-13-19)14-11-18-5-3-2-4-6-18;/h2-10,19H,11-16H2,1H3;1H
INCHI Key: HZRPUQURUAXOHB-UHFFFAOYSA-N
Molecular Weight: 417.4
Canonical SMILES: CC1=C(ON=C1C2CCN(CC2)CCC3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl
Isomeric SMILES: N/A
Molecular Formula: C23H26Cl2N2O

Compound Supplier

Supplier Name: Tocris Bioscience
Catalog #: 1004
Lot #: 2A/171873

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C23H25ClN2O 381.17282; found 381.17493

Dose Response Curve

Platform ID: L741742
Min: -5.7324; Max: 58.2869

IC	Concentration (µM)
IC10	N/A
IC20	4.3609
IC30	5.6579
IC40	7.0041
IC50	8.5196
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 03
Dose: 5µM
Days of incubation: 8
Doublings: 7.1
Numbers of reads: 12019422

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
6/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
SLC5A3	-3.25	<0.01
KDSR	-3.17	<0.01
VAC14	-3.00	0.02
ODC1	-2.77	0.02
C7orf55-LUC7L2	-2.62	0.06
KIAA1432	-2.61	0.04
TRIP4	-2.56	0.05
FIG4	-2.49	0.05
ATP6V1A	-2.49	0.32
FLVCR1	-2.43	0.06
SCAP	-2.42	0.06
CENPA	-2.41	0.12
COG7	-2.29	0.12
UNC50	-2.22	0.15
TRIP12	-2.20	0.16
CNTNAP5	-2.16	0.18
AVPI1	-2.15	0.18
RAB1B	-2.14	0.18
ZC3H18	-2.14	0.32
TBC1D7	-2.13	0.18
KIAA1549L	-2.12	0.26
PITPNB	-2.12	0.18
DOLK	-2.11	0.26
MBTPS1	-2.10	0.33
GCLC	-2.09	0.26
KIR3DL2	-2.07	0.22
MAP3K1	-2.07	0.27
SPTSSA	-2.07	0.22
SPTLC1	-2.06	0.23
SLC25A1	-2.05	0.23
TMSB15B	1.93	0.86
APOBEC3D	1.94	0.62
NKAIN2	1.94	0.50
SLC1A3	1.94	0.50
CRIP1	1.95	0.50
OR10X1	1.96	0.62
TSNARE1	1.97	0.50
CXCL12	1.97	0.50
RAB44	1.98	0.50
EIF3D	1.99	0.60
GNL2	1.99	0.60
EIF5	2.00	0.80
USP11	2.01	0.50
RPL36AL	2.01	0.69
NDC80	2.02	0.86
AGBL1	2.06	0.50
CCDC73	2.11	0.47
MYH7B	2.17	0.50
NAA16	2.19	0.44
MPV17L2	2.20	0.44
HCFC1R1	2.20	0.47
DCAF8L1	2.21	0.47
VWA8	2.22	0.44
MPRIP	2.24	0.50
CDC20	2.31	0.69
GJD4	2.33	0.44
BECN1	2.39	0.44
RPS6KA5	2.41	0.47
OR51Q1	2.47	0.44
RARS	2.57	0.81

Screen	Correlation	Plot
ZLN024 50μM R08 exp538	0.07	View
SGC2043 10μM R03 exp152	0.064	View
Q15 1 to 2μM on day4 R04 exp164	0.061	View
SB203580 25μM R03 exp149	0.054	View
BH1 1μM R04 exp169	0.075	View
BS-181 20μM R08 exp461	0.069	View
IU1-47 25μM R04 exp182	0.054	View
Ibrutinib 10μM R08 exp442	0.051	View
Chlorpromazine 10μM R07 exp344	0.051	View

Last modified: 2026/01/15 21:36
by 127.0.0.1