MAP3K1

Gene Information

Official Symbol: MAP3K1
Official Name: mitogen-activated protein kinase kinase kinase 1
Aliases and Previous Symbols: N/A
Entrez ID: 4214
UniProt: Q13233
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012].
UniProt Summary: Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF- kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
L-74142 5μM R03 exp131	-2.07
Genistein 15μM R07 exp360	-1.93
All-trans-Retinoic-Acid 8μM R07 exp333	-1.9
VE-822 0.04μM R06 exp300	-1.8
Zebularine 20μM R07 exp423	1.72
BI-6727 0.0125μM R03 exp97	1.82

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5150
Expression level (log2 read counts): 5.12

Expression Distribution

Pkinase Tyr
Pkinase

MAP kinase kinase kinase activity
MyD88-dependent toll-like receptor signaling pathway
activation of MAPKK activity
cellular response to mechanical stimulus
toll-like receptor signaling pathway
pattern recognition receptor signaling pathway
stress-activated protein kinase signaling cascade
Fc-epsilon receptor signaling pathway
response to mechanical stimulus
innate immune response-activating signal transduction
protein kinase activity
Fc receptor signaling pathway
activation of innate immune response
positive regulation of MAP kinase activity
cellular response to environmental stimulus
cellular response to abiotic stimulus
activation of protein kinase activity
cellular response to external stimulus
positive regulation of protein serine/threonine kinase activity
positive regulation of innate immune response
regulation of MAP kinase activity
positive regulation of response to biotic stimulus
protein serine/threonine kinase activity
MAPK cascade
signal transduction by protein phosphorylation
regulation of innate immune response
protein kinase binding
positive regulation of defense response
immune response-regulating cell surface receptor signaling pathway
positive regulation of multi-organism process
regulation of protein serine/threonine kinase activity
regulation of response to biotic stimulus
positive regulation of protein kinase activity
positive regulation of MAPK cascade
immune response-activating signal transduction
positive regulation of kinase activity
immune response-regulating signaling pathway
positive regulation of response to external stimulus
activation of immune response
positive regulation of transferase activity