VE-822 0.04μM R06 exp300
Mechanism of Action
Inhibits ATR
- Class / Subclass 1: DNA Damage, Repair and Replication / Checkpoint Signaling Inhibitor
- Class / Subclass 2: Signal Transduction / Kinase Inhibitor
Technical Notes
Compound References
- PubChem Name: Berzosertib
- Synonyms: VE-822; VX-970
- CAS #: 1232416-25-9
- PubChem CID: 59472121
- IUPAC: 3-[3-[4-(methylaminomethyl)phenyl]-1,2-oxazol-5-yl]-5-(4-propan-2-ylsulfonylphenyl)pyrazin-2-amine
- INCHI Name: InChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)
- INCHI Key: JZCWLJDSIRUGIN-UHFFFAOYSA-N
- Molecular Weight: 463.6
- Canonical SMILES: CC(C)S(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C3=CC(=NO3)C4=CC=C(C=C4)CNC)N
- Isomeric SMILES: N/A
- Molecular Formula: C24H25N5O3S
Compound Supplier
- Supplier Name: Med Chem Express
- Catalog #: HY-13902
- Lot #: 17079
Compound Characterization
Characterization data not available.
Dose Response Curve
- Platform ID: VE-822
- Min: -5.9628; Max: 99.8728
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | 0.0441 |
| IC40 | N/A |
| IC50 | 0.0816 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 06
- Dose: 40nM
- Days of incubation: 8
- Doublings: 7.2
- Numbers of reads: 8181743
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
VE-822 0.04μM R06 exp300
