SMAD9

Entrez Summary: The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010].
UniProt Summary: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vinblastine 0.002μM R01 exp60	-2.28
Quercetin 20μM R08 exp517	-2.01
Rapamycin 10μM R00 exp30	-1.94
Tubastatin-A 2.5μM R07 exp417	-1.94
Oligomycin-A 2μM R00 exp25	-1.9
VE-822 0.04μM R06 exp300	-1.87
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.85
2-Methoxyestradiol 0.2μM R01 exp40	-1.78
UMK57 1μM R01 exp59	-1.72
NFN1 1μM R03 exp100	1.79
Epothilone-B 0.0015μM R05 exp231	2.1

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
SMAD protein complex
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
SMAD protein signal transduction
intracellular
BMP signaling pathway
transforming growth factor beta receptor signaling pathway
cellular response to BMP stimulus
response to BMP
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
transmembrane receptor protein serine/threonine kinase signaling pathway
transcription factor complex
cellular response to growth factor stimulus
response to growth factor
enzyme linked receptor protein signaling pathway
positive regulation of transcription by RNA polymerase II
cellular response to endogenous stimulus
DNA binding
response to endogenous stimulus
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process