Quercetin 20μM R08 exp517

General kinase inhibitor, may inhibit NF-‘_B, anti-oxidant, putative senolytic

Class / Subclass 1: Signal Transduction / Kinase Inhibitor
Class / Subclass 2: Gene Regulation / Transcription Inhibitor
Class / Subclass 3: Uncharacterized Mechanism / Natural Product

Compound References

PubChem Name: Quercetin dihydrate
Synonyms: N/A
CAS #: 6151-25-3
PubChem CID: 5284452
IUPAC: 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one;dihydrate
INCHI Name: InChI=1S/C15H10O7.2H2O/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6;;/h1-5,16-19,21H;2*1H2
INCHI Key: GMGIWEZSKCNYSW-UHFFFAOYSA-N
Molecular Weight: 338.27
Canonical SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O.O.O
Isomeric SMILES: N/A
Molecular Formula: C15H14O9

Compound Supplier

Supplier Name: Sigma-Aldrich
Catalog #: Q0125
Lot #: 113K1051

Compound Characterization

Characterization data not available.

Dose Response Curve

Platform ID: Quercetin
Min: -18.5542; Max: 12.6779

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 08
Dose: 20µM
Days of incubation: 8
Doublings: 3.4
Numbers of reads: 18650040

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
43/17	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
GAK	-3.44	<0.01
BRD1	-3.07	<0.01
MCM9	-3.05	<0.01
CNOT8	-3.03	<0.01
RPS15A	-3.01	0.20
TCF4	-2.98	<0.01
NPRL3	-2.96	0.01
PCGF1	-2.96	<0.01
SEPHS1	-2.90	<0.01
BCL2	-2.88	<0.01
CNOT2	-2.87	<0.01
GTSE1	-2.86	<0.01
RANBP1	-2.83	<0.01
NPRL2	-2.74	0.03
RETSAT	-2.68	0.01
MSI2	-2.61	0.01
VPS51	-2.59	0.04
KMT2D	-2.59	0.01
HIST1H2AG	-2.56	0.03
SLC25A37	-2.54	0.03
SLC52A2	-2.52	0.02
RAET1L	-2.50	0.02
TACC3	-2.50	0.02
ANKRD17	-2.49	0.03
ZNF451	-2.48	0.03
DLGAP5	-2.46	0.02
CYP4Z1	-2.45	0.02
KNTC1	-2.44	0.04
EYA2	-2.43	0.04
ELMSAN1	-2.43	0.03
NSUN2	2.26	0.06
UBE3A	2.27	0.06
GLRX5	2.27	0.15
SP1	2.29	0.06
CLVS2	2.31	0.06
NDUFS5	2.33	0.13
MS4A13	2.34	0.43
ME2	2.35	0.05
PRRC2C	2.37	0.07
ZNF737	2.41	0.06
TIMM17A	2.44	0.06
FBXO11	2.49	0.02
GATA3	2.50	0.02
TAF3	2.65	0.05
EIF4A1	2.69	0.02
TP53	2.71	0.02
PDSS1	2.78	0.02
KIF18B	2.80	<0.01
ALAS1	2.82	0.06
KIAA1328	2.82	0.01
SLFN11	2.85	<0.01
COQ6	3.03	0.01
HCCS	3.07	0.01
PPP6R3	3.07	<0.01
HMBS	3.21	<0.01
ALAD	3.26	<0.01
AHCYL1	3.57	<0.01
BAK1	3.64	<0.01
TAF5L	4.06	<0.01
MARCH5	4.09	<0.01

Screen	Correlation	Plot
UMK57 1μM R01 exp59	0.105	View
Thimerosal 0.85μM R08 exp529	0.087	View
Vincristine 0.0005μM R04 exp190	0.086	View
Taxol 0.004μM R03 exp103	0.075	View
UM131593 0.2μM R03 exp106	0.071	View
Tubacin 1.6μM R07 exp416	0.069	View
Sulforaphane 9μM R08 exp525	0.069	View
UM0125461 0.74μM R02 exp84	0.067	View
Vinblastine 0.002μM R01 exp60	0.067	View
Sulforaphane 9μM R08 exp526 no dilution day6	0.065	View
UMK57 0.6μM R03 exp107	0.062	View
SNS-032 15μM R08 exp443	0.06	View
RO-3307 4.7μM R02 exp80	0.06	View
TRAIL 5ng/ml R00 exp35	0.058	View
Trimetrexate 0.03μM R08 exp535	0.058	View
THZ1 0.06μM R08 exp531	0.055	View
Rucaparib 6.5μM R08 exp520	0.055	View
TRAIL 50ng/ml R00 exp36	0.055	View
S-trityl-L-cysteine 0.5μM R05 exp243	0.055	View
Resveratrol 16μM R03 exp147	0.054	View
Dynasore 7μM R08 exp436	0.106	View
BML-284 0.09μM R08 exp460	0.106	View
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	0.101	View
Mdivi-1 15μM R05 exp217	0.095	View
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	0.09	View
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	0.088	View
3-Bromopyruvate 7μM R04 exp175	0.087	View
Aphidicolin 0.4μM R08 exp440	0.082	View
Demecolcine 0.03μM R05 exp228	0.082	View
Pterostilbene 16μM R02 exp78	0.079	View
Cryptotanshinone 12μM R05 exp227	0.073	View
GSK626616 14μM R08 exp485	0.073	View
Dorsomorphin 5μM R07 exp357	0.071	View
Colchicine 0.009μM R05 exp215	0.07	View
Nutlin-3A 1.6μM R06 exp294	0.07	View
Artemisinin 50μM R08 exp450	0.07	View
Docosahexaenoic-acid 50μM R07 exp356	0.069	View
LY2090314 0.003μM R08 exp500 no dilution day6	0.068	View
Dynasore 10μM R04 exp180	0.068	View
2-Methoxyestradiol 0.55μM R07 exp310	0.068	View
Diepoxybutane 3μM R07 exp354	0.067	View
Olaparib 4μM R08 exp512	0.067	View
LY2090314 0.003μM R08 exp499	0.065	View
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	0.064	View
Deferoxamine 11μM R07 exp350	0.063	View
Centrinone 0.5μM R07 exp343	0.063	View
BVD-523 15μM R02 exp67	0.063	View
Genistein 15μM R07 exp360	0.063	View
Epothilone-B 0.0015μM R05 exp231	0.062	View
PU-H71 1μM R08 exp515	0.062	View
CI-1040 9.5μM R08 exp472	0.059	View
CAY10603 0.55μM R08 exp467	0.059	View
Hydroxyurea 100μM R07 exp329	0.058	View
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	0.058	View
CR131-b 0.005μM R08 exp474	0.058	View
Benzoate 20000μM R08 exp456	0.058	View
Lead acetate 2000μM R08 exp498 no dilution day6	0.057	View
Atovaquone 15μM R08 exp451	0.055	View
AICAR 240μM R03 exp116	0.054	View
Bortezomib 0.005μM R00 exp6	0.054	View
MLN-4924 0.2μM R00 exp21	0.053	View
5-Azacytidine 2μM R07 exp330	0.052	View
LLY-283 2.6μM R06 exp290	0.051	View
Mitomycin-C 0.06μM R08 exp503	0.051	View

GO Term	Fold Change	Genes
protoporphyrinogen IX biosynthetic process	207.11	ALAD,HMBS,ALAS1
protoporphyrinogen IX metabolic process	165.69	ALAD,HMBS,ALAS1
release of cytochrome c from mitochondria	78.90	BAK1,TP53,PMAIP1
positive regulation of release of cytochrome c from mitochondria	69.04	BAK1,TP53,PMAIP1
heme biosynthetic process	66.28	ALAD,HMBS,ALAS1
tetrapyrrole biosynthetic process	59.18	ALAD,HMBS,ALAS1
porphyrin-containing compound biosynthetic process	59.18	ALAD,HMBS,ALAS1
positive regulation of mitochondrion organization	30.26	MARCHF5,BAK1,TP53,PMAIP1
mitochondrial membrane	7.83	MARCHF5,BAK1,HCCS,COQ6,ALAS1,TIMM17A,NDUFS5,PMAIP1,SLC25A51,YME1L1
organelle inner membrane	7.58	HCCS,COQ6,ALAS1,TIMM17A,NDUFS5,SLC25A51,YME1L1
mitochondrial envelope	7.35	MARCHF5,BAK1,HCCS,COQ6,ALAS1,TIMM17A,NDUFS5,PMAIP1,SLC25A51,YME1L1

Quercetin 20μM R08 exp517

Mechanism of Action

Technical Notes

Compound References

Compound Supplier

Compound Characterization

Dose Response Curve

Screen Summary

Screen Results