ZNF451

Gene Information

Official Symbol: ZNF451
Official Name: zinc finger protein 451
Aliases and Previous Symbols: N/A
Entrez ID: 26036
UniProt: Q9Y4E5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300- mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). {ECO:0000250|UniProtKB:Q8C0P7, ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:24324267, ECO:0000269|PubMed:26524493, ECO:0000269|PubMed:26524494}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Genistein 15μM R07 exp360	-3.92
Etoposide 0.1μM R05 exp198	-3.19
Dorsomorphin 5μM R07 exp357	-2.96
Pyridostatin 4μM R05 exp240	-2.57
Quercetin 20μM R08 exp517	-2.48
Etoposide 0.3μM R05 exp199	-2.36
TRAIL 5ng/ml R00 exp35	1.72

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12246
Expression level (log2 read counts): 6.74

Expression Distribution

negative regulation of histone H3-K9 acetylation
negative regulation of transcription initiation from RNA polymerase II promoter
negative regulation of DNA-templated transcription, initiation
SUMO ligase activity
regulation of histone H3-K9 acetylation
negative regulation of histone acetylation
negative regulation of peptidyl-lysine acetylation
negative regulation of protein acetylation
regulation of transcription initiation from RNA polymerase II promoter
RNA polymerase II core promoter sequence-specific DNA binding
regulation of DNA-templated transcription, initiation
negative regulation of histone modification
histone methyltransferase complex
regulation of histone acetylation
negative regulation of chromatin organization
regulation of peptidyl-lysine acetylation
protein sumoylation
regulation of protein acetylation
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
PML body
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of chromosome organization
regulation of histone modification
negative regulation of cellular response to growth factor stimulus
regulation of chromatin organization
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
transcription corepressor activity
regulation of cellular response to growth factor stimulus
peptidyl-lysine modification
regulation of chromosome organization
negative regulation of organelle organization
negative regulation of protein modification process
negative regulation of cellular component organization
protein modification by small protein conjugation
negative regulation of transcription by RNA polymerase II
peptidyl-amino acid modification
protein modification by small protein conjugation or removal