GATA3
Gene Information
- Official Symbol: GATA3
- Official Name: GATA binding protein 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 2625
- UniProt: P23771
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009].
- UniProt Summary: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. {ECO:0000269|PubMed:23824597}.
Pfam Domains GO Terms
Pfam Domains
| GATA |
GO Terms
| parathyroid hormone secretion |
| negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation |
| regulation of cell proliferation involved in mesonephros development |
| pro-T cell differentiation |
| type IV hypersensitivity |
| negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation |
| negative regulation of cell proliferation involved in mesonephros development |
| negative regulation of epithelial tube formation |
| regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation |
| regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation |
| hypersensitivity |
| canonical Wnt signaling pathway involved in metanephric kidney development |
| regulation of cellular response to X-ray |
| Wnt signaling pathway involved in kidney development |
| cell-cell signaling involved in metanephros development |
| cell-cell signaling involved in kidney development |
| T-helper 2 cell differentiation |
| positive regulation of thyroid hormone generation |
| ureteric bud formation |
| negative regulation of DNA demethylation |
| mast cell differentiation |
| negative regulation of mesonephros development |
| positive regulation of histone H3-K14 acetylation |
| regulation of ureteric bud formation |
| ureter maturation |
| positive regulation of epithelial tube formation |
| positive regulation of ureteric bud formation |
| negative regulation of mammary gland epithelial cell proliferation |
| regulation of thyroid hormone generation |
| interleukin-2 receptor binding |
| negative regulation of cell proliferation involved in kidney development |
| nephric duct formation |
| interleukin-4 secretion |
| positive regulation of interleukin-13 secretion |
| positive regulation of interleukin-5 secretion |
| regulation of histone H3-K14 acetylation |
| positive regulation of T-helper 2 cell cytokine production |
| interleukin-4 production |
| mesonephric tubule formation |
| norepinephrine biosynthetic process |
| regulation of DNA demethylation |
| ureter morphogenesis |
| parathyroid gland development |
| type 2 immune response |
| acute inflammatory response to antigenic stimulus |
| positive regulation of histone H3-K9 acetylation |
| regulation of interleukin-5 secretion |
| interferon-gamma secretion |
| regulation of interleukin-13 secretion |
| regulation of T-helper 2 cell cytokine production |
| cellular response to interferon-alpha |
| endocrine hormone secretion |
| regulation of histone H3-K27 methylation |
| nephric duct morphogenesis |
| lymphoid progenitor cell differentiation |
| norepinephrine metabolic process |
| regulation of nephron tubule epithelial cell differentiation |
| positive regulation of interleukin-5 production |
| otic vesicle development |
| regulation of histone H3-K9 acetylation |
| regulation of cell proliferation involved in kidney development |
| mesenchymal to epithelial transition |
| ureter development |
| positive regulation of interleukin-13 production |
| positive regulation of hormone metabolic process |
| nephric duct development |
| negative regulation of fibroblast growth factor receptor signaling pathway |
| positive regulation of type 2 immune response |
| negative regulation of morphogenesis of an epithelium |
| negative regulation of kidney development |
| HMG box domain binding |
| nephron tubule formation |
| regulation of mammary gland epithelial cell proliferation |
| interferon-gamma production |
| positive regulation of T cell cytokine production |
| regulation of epithelial tube formation |
| thymic T cell selection |
| catechol-containing compound biosynthetic process |
| regulation of epithelial cell differentiation involved in kidney development |
| catecholamine biosynthetic process |
| cardiac right ventricle morphogenesis |
| embryonic hemopoiesis |
| regulation of establishment of cell polarity |
| response to interferon-alpha |
| animal organ maturation |
| sympathetic nervous system development |
| positive regulation of mesonephros development |
| regulation of interleukin-13 production |
| uterus development |
| regulation of interleukin-5 production |
| negative regulation of interleukin-2 production |
| positive regulation of interleukin-4 production |
| inflammatory response to antigenic stimulus |
| enhancer sequence-specific DNA binding |
| regulation of establishment or maintenance of cell polarity |
| regulation of mesonephros development |
| positive regulation of transcription regulatory region DNA binding |
| negative regulation of embryonic development |
| pharyngeal system development |
| T-helper cell differentiation |
| regulation of interleukin-4 production |
| regulation of histone H3-K4 methylation |
| CD4-positive, alpha-beta T cell differentiation involved in immune response |
| alpha-beta T cell differentiation involved in immune response |
| alpha-beta T cell activation involved in immune response |
| aortic valve morphogenesis |
| TOR signaling |
| cellular response to interleukin-4 |
| regulation of fibroblast growth factor receptor signaling pathway |
| regulation of type 2 immune response |
| positive regulation of histone acetylation |
| negative regulation of endothelial cell apoptotic process |
| proximal promoter sequence-specific DNA binding |
| response to interleukin-4 |
| regulation of T cell cytokine production |
| aortic valve development |
| T cell differentiation involved in immune response |
| phosphatidylinositol 3-kinase signaling |
| positive regulation of peptidyl-lysine acetylation |
| negative regulation of interferon-gamma production |
| phenol-containing compound biosynthetic process |
| negative regulation of animal organ morphogenesis |
| positive regulation of morphogenesis of an epithelium |
| CD4-positive, alpha-beta T cell differentiation |
| positive regulation of embryonic development |
| semi-lunar valve development |
| regulation of hormone metabolic process |
| CD4-positive, alpha-beta T cell activation |
| T cell selection |
| cell fate determination |
| positive regulation of kidney development |
| positive regulation of protein acetylation |
| negative regulation of epithelial cell apoptotic process |
| T cell mediated immunity |
| catecholamine metabolic process |
| catechol-containing compound metabolic process |
| autonomic nervous system development |
| thymus development |
| negative regulation of fat cell differentiation |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| T cell differentiation in thymus |
| positive regulation of T cell mediated immunity |
| endocrine process |
| cytokine secretion |
| E-box binding |
| regulation of endothelial cell apoptotic process |
| alpha-beta T cell differentiation |
| cochlea development |
| heart valve morphogenesis |
| regulation of transcription regulatory region DNA binding |
| ureteric bud morphogenesis |
| mesonephric tubule morphogenesis |
| regulation of interleukin-2 production |
| positive regulation of cytokine production involved in immune response |
| regulation of kidney development |
| positive regulation of DNA binding |
| regulation of histone acetylation |
| response to gamma radiation |
| regulation of CD4-positive, alpha-beta T cell activation |
| heart valve development |
| alpha-beta T cell activation |
| regulation of alpha-beta T cell differentiation |
| regulation of peptidyl-lysine acetylation |
| T cell activation involved in immune response |
| nephron tubule morphogenesis |
| regulation of histone methylation |
| nephron epithelium morphogenesis |
| lymphocyte migration |
| nephron morphogenesis |
| renal tubule morphogenesis |
| acute inflammatory response |
| regulation of T cell mediated immunity |
| regulation of protein acetylation |
| phosphatidylinositol-mediated signaling |
| regulation of hematopoietic stem cell differentiation |
| hormone secretion |
| ventricular septum development |
| cardiac ventricle morphogenesis |
| inositol lipid-mediated signaling |
| response to estrogen |
| transcription regulatory region sequence-specific DNA binding |
| nephron tubule development |
| lens development in camera-type eye |
| regulation of epithelial cell apoptotic process |
| renal tubule development |
| erythrocyte differentiation |
| hormone transport |
| positive regulation of animal organ morphogenesis |
| positive regulation of T cell differentiation |
| phenol-containing compound metabolic process |
| metanephros development |
| regulation of cytokine production involved in immune response |
| kidney morphogenesis |
| ureteric bud development |
| regulation of hematopoietic progenitor cell differentiation |
| mesonephric tubule development |
| hematopoietic progenitor cell differentiation |
| mesonephric epithelium development |
| post-embryonic development |
| erythrocyte homeostasis |
| canonical Wnt signaling pathway |
| mesonephros development |
| positive regulation of histone modification |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| nephron epithelium development |
| positive regulation of production of molecular mediator of immune response |
| inner ear morphogenesis |
| positive regulation of endothelial cell migration |
| regulation of interferon-gamma production |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of chromatin organization |
| cellular response to BMP stimulus |
| regulation of cytokine biosynthetic process |
| response to BMP |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| myeloid cell homeostasis |
| cardiac septum development |
| lymphocyte activation involved in immune response |
| myeloid leukocyte differentiation |
| regulation of stem cell differentiation |
| ear morphogenesis |
| neuron migration |
| endocrine system development |
| negative regulation of DNA metabolic process |
| regulation of fat cell differentiation |
| embryonic epithelial tube formation |
| negative regulation of epithelial cell proliferation |
| nephron development |
| regulation of DNA binding |
| cardiac chamber morphogenesis |
| response to ethanol |
| cardiac ventricle development |
| kidney epithelium development |
| regulation of embryonic development |
| epithelial tube formation |
| positive regulation of leukocyte mediated immunity |
| male gonad development |
| development of primary male sexual characteristics |
| anatomical structure maturation |
| T cell differentiation |
| negative regulation of inflammatory response |
| regulation of T cell differentiation |
| positive regulation of cytokine secretion |
| regulation of production of molecular mediator of immune response |
| positive regulation of epithelial cell migration |
| regulation of epithelial cell differentiation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| morphogenesis of embryonic epithelium |
| regulation of histone modification |
| negative regulation of cellular response to growth factor stimulus |
| tube formation |
| positive regulation of leukocyte differentiation |
| response to ionizing radiation |
| cytokine production |
| regulation of lymphocyte mediated immunity |
| male sex differentiation |
| regulation of endothelial cell migration |
| cell maturation |
| protein secretion |
| protein dimerization activity |
| establishment of protein localization to extracellular region |
| regulation of adaptive immune response |
| chromatin remodeling |
| positive regulation of protein kinase B signaling |
| protein localization to extracellular region |
| regulation of lymphocyte differentiation |
| signal release |
| cardiac chamber development |
| peptide secretion |
| positive regulation of chromosome organization |
| T cell receptor signaling pathway |
| positive regulation of binding |
| regulation of morphogenesis of an epithelium |
| organic hydroxy compound biosynthetic process |
| positive regulation of hemopoiesis |
| regulation of chromatin organization |
| inner ear development |
| homeostasis of number of cells |
| positive regulation of T cell activation |
| regulation of cytokine secretion |
| regulation of leukocyte mediated immunity |
| regulation of neuron apoptotic process |
| negative regulation of defense response |
| gonad development |
| positive regulation of leukocyte cell-cell adhesion |
| development of primary sexual characteristics |
| transcription regulatory region DNA binding |
| positive regulation of immune effector process |
| myeloid cell differentiation |
| regulation of protein kinase B signaling |
| regulation of epithelial cell migration |
| ear development |
| response to alcohol |
| T cell activation |
| nuclear chromatin |
| lymphocyte differentiation |
| developmental maturation |
| cellular response to tumor necrosis factor |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| cell fate commitment |
| heart morphogenesis |
| positive regulation of cell-cell adhesion |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| axon guidance |
| neuron projection guidance |
| response to tumor necrosis factor |
| sex differentiation |
| lymphocyte mediated immunity |
| kidney development |
| positive regulation of protein secretion |
| regulation of cellular response to growth factor stimulus |
| regulation of leukocyte differentiation |
| negative regulation of cell motility |
| negative regulation of cytokine production |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| response to virus |
| protein deubiquitination |
| renal system development |
| transcription coactivator activity |
| embryonic organ morphogenesis |
| positive regulation of peptide secretion |
| blood coagulation |
| coagulation |
| antigen receptor-mediated signaling pathway |
| regulation of leukocyte cell-cell adhesion |
| protein modification by small protein removal |
| hemostasis |
| response to antibiotic |
| epithelial tube morphogenesis |
| negative regulation of cellular component movement |
| regulation of neuron death |
| camera-type eye development |
| regulation of T cell activation |
| urogenital system development |
| negative regulation of locomotion |
| leukocyte differentiation |
| transcription factor binding |
| regulation of epithelial cell proliferation |
| regulation of inflammatory response |
| humoral immune response |
| regulation of chromosome organization |
| regulation of DNA metabolic process |
| cell-cell signaling by wnt |
| Wnt signaling pathway |
| eye development |
| positive regulation of lymphocyte activation |
| visual system development |
| negative regulation of response to external stimulus |
| sensory system development |
| axonogenesis |
| in utero embryonic development |
| regulation of binding |
| leukocyte migration |
| lymphocyte activation |
| developmental growth |
| growth |
| regulation of cell-cell adhesion |
| positive regulation of secretion by cell |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| axon development |
| gland development |
| positive regulation of cell activation |
| reproductive structure development |
| positive regulation of protein transport |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| reproductive system development |
| morphogenesis of an epithelium |
| cell morphogenesis involved in neuron differentiation |
| embryonic organ development |
| positive regulation of secretion |
| response to radiation |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| immune response-activating cell surface receptor signaling pathway |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| organic hydroxy compound metabolic process |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of immune effector process |
| wound healing |
| neuron projection morphogenesis |
| transcription by RNA polymerase II |
| immune response-regulating cell surface receptor signaling pathway |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| regulation of peptide secretion |
| regulation of body fluid levels |
| regulation of neuron projection development |
| inflammatory response |
| cellular response to growth factor stimulus |
| positive regulation of cell migration |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| response to toxic substance |
| cell part morphogenesis |
| regulation of lymphocyte activation |
| positive regulation of cell motility |
| heart development |
| response to growth factor |
| regulation of hormone levels |
| positive regulation of cellular component movement |
| sensory organ development |
| chemotaxis |
| positive regulation of locomotion |
| taxis |
| cell morphogenesis involved in differentiation |
| hemopoiesis |
| immune response-activating signal transduction |
| tissue morphogenesis |
| embryonic morphogenesis |
| response to wounding |
| negative regulation of cell cycle |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| adaptive immune response |
| positive regulation of organelle organization |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| activation of immune response |
| chordate embryonic development |
| transcription, DNA-templated |
| regulation of cell activation |
| nucleic acid-templated transcription |
| immune system development |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| tube morphogenesis |
| regulation of neuron differentiation |
| neuron projection development |
| developmental process involved in reproduction |
| cytokine-mediated signaling pathway |
| DNA-binding transcription factor activity |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| epithelial cell differentiation |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cytokine production |
| chromatin organization |
| regulation of protein transport |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| cell morphogenesis |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| leukocyte mediated immunity |
| innate immune response |
| regulation of secretion |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| zinc ion binding |
| tube development |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of immune response |
| circulatory system development |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| regulation of cell motility |
| regulation of nervous system development |
| leukocyte activation |
| regulation of cell development |
| negative regulation of developmental process |
| defense response to other organism |
| animal organ morphogenesis |
| cell migration |
| positive regulation of cell differentiation |
| embryo development |
| regulation of locomotion |
| protein modification by small protein conjugation or removal |
| positive regulation of transport |
| negative regulation of cell death |
| regulation of cellular component movement |
| secretion by cell |
| cellular response to cytokine stimulus |
| neuron differentiation |
| response to drug |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| export from cell |
| regulation of anatomical structure morphogenesis |
| chromosome organization |
| cell activation |
| localization of cell |
| cell motility |
| immune effector process |
| regulation of response to external stimulus |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| epithelium development |
| cell-cell signaling |
| secretion |
| plasma membrane bounded cell projection organization |
| positive regulation of immune system process |
| regulation of immune response |
| cell projection organization |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| proteolysis |
| regulation of organelle organization |
| response to other organism |
| organic cyclic compound biosynthetic process |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| organonitrogen compound biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| protein transport |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| peptide transport |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| amide transport |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| RNA metabolic process |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| nitrogen compound transport |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 16/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 8/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 3/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1521
- Expression level (log2 read counts): 3.86
Expression Distribution
GATA3 Expression in NALM6 Cells: 3.86
