RRM1

Gene Information

Official Symbol: RRM1
Official Name: ribonucleotide reductase catalytic subunit M1
Aliases and Previous Symbols: N/A
Entrez ID: 6240
UniProt: P23921
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
UniProt Summary: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-2536 0.02μM R03 exp96	-2.46
GSK591 2.6μM R03 exp128	-2.02
A-196 10μM R03 exp114	1.89
SGC0946 7μM R03 exp151	1.89
Nicotinamide Riboside 100μM R03 exp139	2.65

Gene	Correlation
PPAP2C	0.836
CCL3L1	0.816
CCL3L3	0.815
SH3D21	0.813
RNF5	0.741
HS6ST1	0.715
SMTN	0.715
TNFAIP2	0.712
CCR7	0.712
CDRT15	0.709
IP6K1	0.698
UBQLN4	0.691
PRR22	0.688
SNRNP48	0.688
SDC4	0.685
PSTPIP2	0.682
HDAC2	0.678
RABL6	0.678
TRIM48	0.677
DCST1	0.669
OR1N1	0.667
ENPP2	0.663
DHX57	0.658
IZUMO1R	0.656
GBAS	0.655
USP37	0.654
SERINC3	0.653
ABLIM3	0.651
RUNX1	0.645
STK25	0.637
PCDHA3	0.635
FRMD8	0.628
NANOS3	0.627
DHDH	0.626
TBC1D1	0.626
DNASE1	0.626
C6orf48	0.625
ZNF414	0.625
ERGIC2	0.624
RILPL1	0.622
BTK	0.62
SLC51A	0.618
ATRN	0.618
CDK4	0.617
IGSF8	0.617
BHLHE22	0.614
DNAH3	0.612
PFKM	0.612
GPR32	0.61
IGFBP4	0.61
CCDC102B	0.609
FBXO24	0.609
PYGM	0.608
GBP7	0.607
NOP56	0.606
CHCHD3	0.606
EFHB	0.606
CLDN7	0.605
NOV	0.604
BNIP3L	0.602
CCRN4L	0.601
EXPH5	0.601
SLC29A3	0.6
WNT9B	0.598
AAED1	0.598
MSANTD4	0.598
RTN4RL2	0.595
EGR2	0.594
DLK1	0.594
LMBR1	0.593
PHC3	0.59
ROGDI	0.589
PSAPL1	0.588
TSPYL5	0.588
DNASE1L1	0.588
FAM111A	0.588
C19orf81	0.587
SHARPIN	0.586
COL28A1	0.585
STK16	0.585
OR10J1	0.584
BRINP3	0.584
KHDRBS3	0.584
GZMB	0.583
SH3RF3	0.583
OR7A5	0.582
RHBG	0.581
SERF1B	0.58
SERF1A	0.579
C3orf33	0.577
TMPRSS5	0.577
PAN3	0.577
ZNF607	0.576
EHD1	0.574
VWA3B	0.573
ABCA5	0.571
ZNF641	0.571
SULT1A4	0.571
HIST2H2BF	0.57
GGN	0.57
SULT1A3	0.57
DPP7	0.569
PCDH12	0.569
MICB	0.569
ACVR2B	0.569
C12orf5	0.568
USP17L2	0.567
TNNT2	0.566
NOP14	0.565
ARL4C	0.565
ZBP1	0.564
DNAJA3	0.564
MRGBP	0.564
GCK	0.564
SNTA1	0.563
ATP5G2	0.563
EBNA1BP2	0.562
GDNF	0.561
THBS4	0.561
CCL24	0.56
DRC1	0.559
NFYA	0.559
EPHA3	0.557
PSMG3	0.555
NDST4	0.554
PSPN	0.553
ATG3	0.553
TMED6	0.552
LPAR2	0.549
PRKCH	0.549
RAB3IP	0.548
GPR68	0.547
CAPZA2	0.547
KLHL10	0.546
GPC4	0.546
ZC3H4	0.546
GLUD1	0.546
MXD1	0.546
NCAPG	0.545
IL10	0.544
CXXC11	0.543
CCDC24	0.543
APBB1	0.543
HTR1E	0.542
MAP4K4	0.542
HPGD	0.542
ZNF839	0.542
NCR3LG1	0.542
C1orf115	0.542
MACF1	0.541
CLDN8	0.54
HSPB1	0.539
GNG10	0.539
AEBP1	0.539
DLC1	0.538
TCN2	0.538
WBSCR27	0.537
MAFB	0.537
UFSP1	0.537
ZNF814	0.537
DISP2	0.537
NXPH4	0.536
TRIM38	0.536
ZNF354B	0.535
DPF1	0.535
HEATR2	0.535
XRCC6	0.534
PPWD1	0.534
FUT4	0.533
DAAM2	0.533
NFKBIA	0.533
SLC1A2	0.533
YTHDF3	0.532
DPP8	0.532
ZNF385A	0.532
CRELD2	0.531
SLC52A3	0.531
GNA15	0.53
MED26	0.53
RD3L	0.53
TCEANC	0.529
BCAS2	0.528
DMD	0.527
DNAJC28	0.527
U2AF2	0.527
CCR1	0.526
SSX2IP	0.526
CUEDC1	0.526
TESK1	0.524
ZNF107	0.524
GGT7	0.524
TNK1	0.523
SLC38A7	0.523
MS4A15	0.522
AGPS	0.522
ANKRD34A	0.522
ZBTB7B	0.521
TRA2A	0.521
MAGEB17	0.521
OR1S1	0.521
VCX3A	0.52
LIN28B	0.52
CKAP4	0.52
CEACAM19	0.52
STAT2	0.519
HMOX1	0.519
GSTA5	0.519
TRAF4	0.518
LRRC4B	0.518
F9	0.518
CTAGE5	0.517
GPHN	0.517
TP73	0.517
C9orf142	0.517
NFATC3	0.517
SOGA1	0.516
ZIC3	0.516
DBI	0.515
C9orf40	0.515
RHOBTB2	0.514
TCF7L2	0.514
CBWD5	0.514
AES	0.514
AGAP3	0.513
ATP5L2	0.512
WNT16	0.512
SLC16A12	0.512
IMP3	0.511
STK39	0.51
KDM1B	0.51
RNF20	0.509
YES1	0.509
ZFP69	0.508
PAK3	0.508
ZFP37	0.508
SRSF1	0.508
ATF7	0.507
PSMD1	0.507
PPID	0.507
GTF2F2	0.507
COL6A6	0.506
DPY19L1	0.505
SLCO5A1	0.505
PIP5K1C	0.503
MED27	0.503
ABCA2	0.503
CRYZL1	0.503
NUP210L	0.502
SFXN3	0.502
ANKRD22	0.502
COCH	0.502
ACSM2A	0.501
ZMAT5	0.501
DCAF12L2	0.501
PROCR	0.501
SLC31A2	0.5
IL5RA	0.499
TMPRSS4	0.499
C5orf48	0.498
PRB4	0.498
GGCX	0.497
TOP2A	0.497
RPS17	0.496
RAP1GDS1	0.496
RABGGTA	0.495
CALR	0.495
BLZF1	0.494
ROPN1	0.494
DOCK4	0.494
SFPQ	0.494
CHD6	0.494
MYT1L	0.494
UBD	0.493
TMPO	0.493
NEUROD6	0.492
SCRT1	0.492
BNC1	0.492
SGTA	0.492
AP2M1	0.491
PRDM4	0.491
CDCA5	0.491
OR3A3	0.491
RAB20	0.491
PRKDC	0.491
KLK1	0.491
FGD3	0.49
CD79A	0.49
ONECUT2	0.49
FSTL4	0.49
MED17	0.49
MED12	0.489
MYB	0.489
C6orf222	0.489
TLDC2	0.489
HIF1A	0.489
PLEKHA6	0.489
FBXO48	0.488
FMNL1	0.488
CNNM4	0.488
C19orf10	0.487
DENND2A	0.487
IL6	0.487
ANAPC2	0.487
PRR11	0.487
CACNA1S	0.487
KRTCAP3	0.486
S100A8	0.486
C1QC	0.486
BLM	0.486
PCID2	0.485
ZNF428	0.485
ARL8A	0.485
FAM198B	0.485
RNF185	0.484
RPS17L	0.484
C3orf17	0.484
OR2A5	0.484
TIGD3	0.484
PRKD2	0.483
MGA	0.483
KCNK12	0.483
H1FX	0.483
WNT7B	0.483
TBC1D10B	0.483
ACO1	0.483
PRDX5	0.482
C15orf59	0.482
FRMPD3	0.482
GLT8D1	0.482
MMP3	0.482
ZNF831	0.482
TCTN3	0.481
CCDC71	0.481
NPHP4	0.481
CHRNA1	0.481
LGI4	0.481
ASCL4	0.481
FGF16	0.481
SLAMF1	0.48
RRP36	0.48
TENC1	0.48
PTPRJ	0.48
KCNN2	0.479
PSMA1	0.479
BLNK	0.479
SPAG8	0.479
NAT1	0.478
SELP	0.478
LRRC39	0.477
MAGEA3	0.477
IQGAP1	0.476
TBC1D8B	0.476
GATA3	0.476
PRKD1	0.476
UIMC1	0.476
S100A7	0.476
C14orf93	0.476
SP5	0.476
RBM28	0.475
TAC3	0.474
EMILIN3	0.474
DHRS7C	0.474
TBPL2	0.474
CNOT3	0.474
SLC24A2	0.474
FERMT3	0.473
PIP5K1A	0.473
CCT4	0.473
LEPRE1	0.472
EPHA10	0.472
IGFN1	0.472
NFX1	0.472
ZFP64	0.472
ATXN1	0.472
KCNAB3	0.472
C15orf27	0.471
SEMA4A	0.471
JMJD1C	0.471
PLEKHA7	0.47
GRHL1	0.469
RMI2	0.469
RRH	0.469
TMEM19	0.469
PITX1	0.469
GIMAP2	0.469
GAD2	0.469
RAB11FIP2	0.469
RASSF10	0.468
MICU1	0.468
TAL2	0.468
PRPF3	0.468
HTR5A	0.468
OR6S1	0.468
DCTN2	0.467
CTNNA2	0.467
FZD1	0.467
SSX7	0.467
ATG4B	0.467
BMPR2	0.466
CST4	0.466
RPS2	0.466
LILRB2	0.465
CYTH2	0.465
RSC1A1	0.465
SAA4	0.465
PLA2G4D	0.464
TAS2R9	0.464
DGKQ	0.464
LRIG2	0.464
PANX2	0.463
SNAP47	0.463
PHKA2	0.463
CDK11A	0.462
RPS13	0.462
FAM65C	0.462
GH2	0.462
CALHM2	0.462
LY6H	0.462
AIDA	0.462
STRN	0.462
WNK1	0.462
SEPHS2	0.461
AFAP1L1	0.461
NOL7	0.461
TPCN2	0.461
DCX	0.461
SLC17A6	0.461
KCND3	0.461
ZNF48	0.461
PLK2	0.46
ZNF486	0.46
SALL2	0.46
NSUN6	0.46
POLR2J	0.46
FAM175A	0.46
ZNF529	0.46
GNAI3	0.459
GBP4	0.459
C8orf86	0.459
COA4	0.459
PNMT	0.459
SESTD1	0.458
SEC14L5	0.458
DPYSL3	0.458
DSG4	0.458
TRIM36	0.457
CD79B	0.457
FIBCD1	0.457
ANKRD54	0.457
FOXD4	0.456
PIH1D1	0.456
VCY1B	0.456
EMR3	0.456
KRT80	0.456
SLC35A2	0.456
SLIT1	0.456
TMIGD2	0.456
GPR17	0.456
ZNF229	0.455
IGF2BP1	0.454
GATAD1	0.454
MLF2	0.454
BCORL1	0.454
LMO7	0.453
VCY	0.453
KLRC2	0.453
PPP2CB	0.453
TMUB1	0.453
TAF7	0.453
FAM212A	0.452
HENMT1	0.452
TTC39B	0.452
GNPAT	0.451
MYO1G	0.451
NICN1	0.451
SKI	0.451
C4orf6	0.451
PAPLN	0.451
C18orf42	0.451
ETFDH	0.451
ACADM	0.451
FGFRL1	0.451
VCX3B	0.451
TREX2	0.451
CCAR2	0.45
PODXL2	0.449
PIK3AP1	0.449
PLCH2	0.449
KIAA1143	0.449
PPAPDC1A	0.449
UNC13D	0.448
PRKCA	0.448
FUBP1	0.448
CDR2	0.448
CDT1	0.447
CEP95	0.447
PCDHGA9	0.447
AHRR	0.447
SLC1A5	0.447
MFSD3	0.447
POLR2J2	0.446
SYNJ2BP	0.446
KCNJ12	0.446
TMC2	0.446
FUT3	0.446
SERTAD4	0.446
CSGALNACT1	0.445
ZCCHC14	0.445
RETNLB	0.445
ANKLE2	0.445
CRTC3	0.445
ELMOD2	0.444
DCTN4	0.444
EPS8L3	0.444
NCAPH	0.444
COL9A1	0.444
DENND3	0.443
NARFL	0.443
HKR1	0.443
COPG1	0.443
POU6F1	0.443
POP5	0.443
SETX	0.443
COQ10A	0.442
PCSK4	0.442
CCNL2	0.442
LARS	0.442
FAM222A	0.442
UGT2B11	0.442
GRINA	0.441
IFNA4	0.441
CC2D2B	0.441
COG2	0.441
REL	0.441
KCNJ9	0.441
SORBS3	0.44
FAM86B2	0.44
PALLD	0.44
PLCB4	0.44
CHMP2A	0.44
PPP1R35	0.44
CCL18	0.44
NF2	0.44
GPR139	0.439
SHISA7	0.439
ZNF74	0.439
GPR45	0.439
ZFX	0.439
NDST1	0.439
XIRP2	0.439
FAM120C	0.439
HIST1H4B	0.438
GSTM5	0.438
DEF6	0.438
EMC9	0.438
TMEM121	0.438
SDC1	0.438
NCF2	0.438
DBX1	0.438
TYW5	0.438
NCOA7	0.438
SETD2	0.438
IPPK	0.437
G6PC3	0.437
MINPP1	0.437
CUL4B	0.437
PRAMEF1	0.437
C11orf42	0.437
GPX4	0.437
HIST1H2BO	0.437
SLC25A5	0.437
TMEM53	0.437
SLC22A15	0.437
ZNF423	0.437
PSD	0.436
NPC1L1	0.436
SULT1E1	0.436
DPP4	0.436
CFAP46	0.436
LRRC43	0.436
FAM179B	0.435
SYNGR3	0.435
CHMP2B	0.435
PRPF31	0.435
PAFAH1B1	0.435
PAX6	0.435
TMEM44	0.435
AMACR	0.435
ADGB	0.434
TMEM14A	0.434
GPR34	0.433
PPP3R1	0.433
DTWD1	0.433
HMGN1	0.433
ERCC1	0.433
ST8SIA3	0.432
SLCO1B3	0.432
HSD3B7	0.432
CCDC104	0.432
SUPT6H	0.432
PCDHB2	0.432
CD36	0.432
DCAF4L2	0.431
CXorf36	0.431
APOBEC3D	0.431
LOC79999	0.431
WIBG	0.431
MBTD1	0.431
IGJ	0.431
KAT6B	0.431
MYLK3	0.431
SGK2	0.431
TMEM254	0.43
NIPSNAP1	0.43
ULK1	0.43
PINLYP	0.43
PRSS53	0.43
NT5C3B	0.43
FAM129B	0.43
IWS1	0.43
MAP3K6	0.429
LRRC30	0.429
C11orf83	0.429
TBC1D14	0.429
MOB1B	0.429
FAM231B	0.429
DSN1	0.429
CNTNAP2	0.428
ANKRD39	0.428
BANP	0.428
SLU7	0.428
FAM122A	0.428
MAFF	0.428
POLI	0.428
ZFP57	0.428
CCL16	0.428
CRTAP	0.428
GFOD1	0.427
PTCH2	0.427
CHML	0.427
KLRF2	0.427
ZBTB49	0.427
GSR	0.427
LIMCH1	0.427
STIM1	0.427
FAM21A	0.427
ATG2B	0.427
CCIN	0.426
PTGES3L	0.426
PLCG2	0.426
FAM107B	0.426
KLHDC1	0.426
DDX58	0.426
IDS	0.426
MDK	0.425
ST8SIA4	0.425
RMDN1	0.425
BID	0.425
TMF1	0.425
ZCCHC12	0.425
SEZ6L	0.425
STAG1	0.425
ANKRD34B	0.425
CYP4F8	0.424
DNAJC12	0.424
TEAD3	0.424
CEP135	0.424
CACTIN	0.423
LIMS2	0.423
WDSUB1	0.423
BSG	0.423
CDK2	0.423
CD300LD	0.423
SPSB2	0.423
USP3	0.423
PTHLH	0.422
CPO	0.422
C5orf46	0.422
MARCH6	0.422
DUSP27	0.422
NUCKS1	0.422
B4GALNT2	0.422
TMEM25	0.422
UNC45A	0.421
CEACAM8	0.421
CIC	0.421
PARD3B	0.421
PCDHB16	0.42
INTS1	0.42
FAM63A	0.42
TTC22	0.42
DEDD	0.42
C3orf83	0.42
PTK2B	0.42
BTNL9	0.42
TINF2	0.419
MAP3K19	0.419
FAM114A2	0.419
HFE	0.419
MYL5	0.419
APOBEC3G	0.419
RPS19	0.419
SLC34A1	0.419
TMEM132D	0.418
ERMARD	0.418
FBL	0.418
DHX8	0.418
ASXL3	0.418
SOCS4	0.418
NBR1	0.418
PHLPP1	0.418
HSPB11	0.418
PRR14	0.417
LILRB4	0.417
GPLD1	0.417
OAS1	0.417
ZNF366	0.417
ARRDC5	0.417
DNAJA1	0.417
ZNF106	0.417
ZNF362	0.416
OR6C75	0.416
ZNF432	0.415
C7orf41	0.415
UCP3	0.415
SPAM1	0.415
MAG	0.415
PEF1	0.414
PSMC1	0.414
TMEM55B	0.414
ZNF844	0.414
GIMAP5	0.413
VSTM1	0.413
HEXA	0.413
PPFIA2	0.413
GFI1	0.413
SSBP4	0.413
PHEX	0.413
NOP16	0.413
NUBP2	0.413
SPC24	0.413
TONSL	0.413
BCAS4	0.412
ALS2CL	0.412
MDM1	0.412
HK1	0.412
ADCY8	0.412
NPIPA5	0.412
KSR2	0.412
POU2F1	0.412
HOMER1	0.412
AURKC	0.412
FUK	0.412
ANKRD18B	0.412
NPW	0.412
IGF2	0.411
TEX13B	0.411
ZFP112	0.411
TNNT1	0.411
RASD1	0.411
TERF1	0.41
HABP2	0.41
OR1J2	0.41
KRT222	0.41
HTR7	0.41
AK4	0.409
ANHX	0.409
PSMB4	0.409
ASTN1	0.409
SCG5	0.409
ADPRHL2	0.409
LRRC18	0.409
OR3A2	0.409
KCNMB2	0.409
MACROD1	0.408
MEIS1	0.408
TGM4	0.408
SERPINB4	0.408
NR0B1	0.408
CCDC66	0.408
MCM7	0.407
FBN1	0.407
CMPK2	0.407
CTSF	0.407
OR4C16	0.407
MICALL2	0.406
INSM2	0.406
RBMX	0.406
CBWD1	0.406
GPATCH2L	0.406
JUNB	0.406
ZNF511	0.405
PSMB3	0.405
GSTP1	0.405
KLHL1	0.405
C16orf89	0.405
CBY1	0.404
LPPR4	0.404
CFAP74	0.404
ARHGAP36	0.404
KCNF1	0.404
PAH	0.404
KCNH7	0.403
LDLRAD2	0.403
C22orf29	0.403
FAM47E	0.403
HOXD12	0.403
KIFC2	0.403
ST6GALNAC2	0.402
CBWD2	0.402
C19orf43	0.402
ANKRD2	0.402
SPARCL1	0.402
ROPN1L	0.402
GYLTL1B	0.402
AQP10	0.402
ARHGAP9	0.402
CBWD3	0.402
ZC3H12B	0.402
SLC22A11	0.401
C2orf80	0.401
FOXR1	0.401
KIAA2013	0.401
RPL26	0.401
C10orf62	0.401
HGFAC	0.401
KDM4E	0.4
FAM47C	0.4
TMEM52	0.4
C6orf136	0.4
FCGR2A	0.4
CHD4	0.4

Global Fraction of Cell Lines Where Essential: 737/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 3
Expression level (log2 read counts): 8.17

Expression Distribution

Ribonuc red lgN
Ribonuc red lgC
ATP-cone

ribonucleoside-diphosphate reductase complex
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
deoxyribonucleotide biosynthetic process
pyrimidine nucleobase metabolic process
cell proliferation in forebrain
nucleobase-containing small molecule interconversion
protein heterotetramerization
disordered domain specific binding
deoxyribonucleotide metabolic process
nucleobase metabolic process
neural precursor cell proliferation
cell projection
pyrimidine-containing compound metabolic process
protein heterooligomerization
male gonad development
development of primary male sexual characteristics
retina development in camera-type eye
response to ionizing radiation
protein tetramerization
male sex differentiation
nuclear envelope
gonad development
DNA replication
development of primary sexual characteristics
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
sex differentiation
camera-type eye development
eye development
visual system development
sensory system development
neuronal cell body
forebrain development
reproductive structure development
reproductive system development
response to radiation
nucleotide metabolic process
nucleoside phosphate metabolic process
protein complex oligomerization
organophosphate biosynthetic process