CTNNA2
Gene Information
- Official Symbol: CTNNA2
- Official Name: catenin alpha 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 1496
- UniProt: P26232
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Vinculin |
GO Terms
| extrinsic component of postsynaptic membrane |
| extrinsic component of presynaptic membrane |
| radial glia guided migration of Purkinje cell |
| modification of postsynaptic actin cytoskeleton |
| negative regulation of Arp2/3 complex-mediated actin nucleation |
| regulation of synapse structural plasticity |
| hindbrain radial glia guided cell migration |
| modification of postsynaptic structure |
| negative regulation of actin nucleation |
| modification of synaptic structure |
| cell migration in hindbrain |
| presynaptic active zone cytoplasmic component |
| prepulse inhibition |
| regulation of Arp2/3 complex-mediated actin nucleation |
| parallel fiber to Purkinje cell synapse |
| postsynaptic density, intracellular component |
| regulation of actin nucleation |
| startle response |
| brain morphogenesis |
| hippocampal mossy fiber to CA3 synapse |
| regulation of neuron migration |
| dendrite morphogenesis |
| adherens junction |
| positive regulation of muscle cell differentiation |
| dendrite development |
| structural constituent of cytoskeleton |
| cell-cell adherens junction |
| neuromuscular process |
| negative regulation of supramolecular fiber organization |
| negative regulation of cytoskeleton organization |
| hindbrain development |
| regulation of muscle cell differentiation |
| regulation of actin filament polymerization |
| lamellipodium |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| basolateral plasma membrane |
| actin filament binding |
| actin cytoskeleton |
| regulation of synapse organization |
| regulation of protein polymerization |
| regulation of synapse structure or activity |
| regulation of actin filament organization |
| synapse organization |
| axon |
| cadherin binding |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| negative regulation of response to external stimulus |
| axonogenesis |
| negative regulation of organelle organization |
| regulation of cellular component size |
| regulation of actin filament-based process |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| regulation of protein complex assembly |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| regulation of neuron projection development |
| cell-cell adhesion |
| regulation of anatomical structure size |
| cell part morphogenesis |
| regulation of cytoskeleton organization |
| cell morphogenesis involved in differentiation |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| cell morphogenesis |
| brain development |
| head development |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of cell migration |
| regulation of cell motility |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of cell differentiation |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| neuron differentiation |
| identical protein binding |
| localization of cell |
| cell motility |
| regulation of response to external stimulus |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| regulation of organelle organization |
| locomotion |
| positive regulation of developmental process |
| nervous system process |
| generation of neurons |
| movement of cell or subcellular component |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| regulation of cell differentiation |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5346
- Expression level (log2 read counts): 0.65
Expression Distribution
CTNNA2 Expression in NALM6 Cells: 0.65
