PLA2G4D

Entrez Summary: N/A
UniProt Summary: Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:14709560). May have a substrate specificity for linoleic acid at the sn-2 position (PubMed:14709560). {ECO:0000269|PubMed:14709560}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PLA2 B
C2

calcium-dependent phospholipase A2 activity
phosphatidylinositol acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
glycerophospholipid catabolic process
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phosphatidylethanolamine acyl-chain remodeling
phosphatidylcholine acyl-chain remodeling
phospholipase A2 activity
phosphatidylglycerol metabolic process
phosphatidylserine metabolic process
phospholipid catabolic process
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
glycerolipid catabolic process
calcium-dependent phospholipid binding
phosphatidylcholine metabolic process
organophosphate catabolic process
phosphatidylinositol metabolic process
ammonium ion metabolic process
cellular lipid catabolic process
cellular modified amino acid metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
lipid catabolic process
glycerophospholipid metabolic process
fatty acid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
monocarboxylic acid metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
calcium ion binding
organophosphate metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxoacid metabolic process
organic acid metabolic process