Thalidomide 20μM R07 exp406 [The Human Chemical-Genetic Interaction Map Project]

IMiD that targets neo-substrates IKZF1/3 for ubiquitination by CUL4A-DDB1-cereblon complex

Class / Subclass 1: Proteostasis / Bivalent Ligand

Compound References

PubChem Name: Thalidomide
Synonyms: N/A
CAS #: 50-35-1
PubChem CID: 5426
IUPAC: 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
INCHI Name: InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
INCHI Key: UEJJHQNACJXSKW-UHFFFAOYSA-N
Molecular Weight: 258.23
Canonical SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
Isomeric SMILES: N/A
Molecular Formula: C13H10N2O4

Compound Supplier

Supplier Name: Cayman Chemical
Catalog #: 14610
Lot #: 0485409-6

Compound Characterization

LCMS: Tr 1.04 min, m/z 259+ [M+H]+

Dose Response Curve

Platform ID: rac-Thalidomide
Min: -5.7941; Max: 9.9969

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 07
Dose: 20µM
Days of incubation: 8
Doublings: 6.9
Numbers of reads: 23258473

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
VEZT	-2.50	0.35
GPR137C	-2.34	0.53
ZNHIT1	-2.27	0.43
MDN1	-2.27	0.70
ZKSCAN7	-2.22	0.43
SESTD1	-2.21	0.43
DUOXA2	-2.17	0.43
RPS6KA6	-2.14	0.43
C7orf55-LUC7L2	-2.12	0.43
TXNL4B	-2.12	0.43
NPRL3	-2.10	0.58
AGPAT1	-2.06	0.59
SOGA3	-2.03	0.60
FZR1	-2.03	0.58
WARS	-2.02	0.58
PLA2G1B	-1.99	0.58
PDAP1	-1.98	0.58
C5orf51	-1.98	0.58
FAM172A	-1.96	0.58
SPEF2	-1.95	0.58
YAP1	-1.95	0.58
CDH1	-1.93	0.58
SDC2	-1.92	0.58
SNF8	-1.91	0.60
DHPS	-1.91	0.73
OR6T1	-1.90	0.58
SRP68	-1.90	0.58
PGAP1	-1.89	0.58
PAM16	-1.88	0.60
ABHD6	-1.87	0.58
METTL8	1.87	0.76
SMC1A	1.88	0.77
CRYBB3	1.88	0.69
G0S2	1.90	0.69
MTRNR2L4	1.90	0.84
EBNA1BP2	1.92	0.69
PDZD7	1.93	0.69
BANP	1.94	0.69
DONSON	1.94	0.76
PAF1	1.96	0.69
SF3B2	1.99	0.76
INO80D	2.05	0.69
SKIV2L2	2.05	0.84
NXPE1	2.06	0.69
TRAPPC6B	2.07	0.69
PRICKLE4	2.07	0.69
NUP205	2.08	0.69
MAPK11	2.11	0.69
LOC100505679	2.14	0.84
CD74	2.18	0.42
PAPSS1	2.19	0.42
KIAA0907	2.19	0.42
A1BG	2.20	0.42
PPAN-P2RY11	2.23	0.69
PPAN	2.24	0.69
SF3A3	2.25	0.76
FANCM	2.37	0.42
GJA10	2.51	0.42
SPC25	2.51	0.69
RPSA	2.69	0.69

Last modified: 2026/01/15 21:36
by 127.0.0.1