SPC25

Entrez Summary: N/A
UniProt Summary: Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:23085020}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 682/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	27/28
bone	25/26
breast	30/33
central nervous system	50/56
cervix	4/4
colorectal	16/17
esophagus	10/13
fibroblast	1/1
gastric	13/16
kidney	17/21
liver	19/20
lung	70/75
lymphocyte	15/16
ovary	22/26
pancreas	24/24
peripheral nervous system	14/16
plasma cell	13/15
prostate	1/1
skin	23/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	27/29
uterus	5/5

Expression Distribution

Spc7
Spindle Spc25

Ndc80 complex
mitotic spindle organization
condensed chromosome kinetochore
microtubule cytoskeleton organization involved in mitosis
spindle organization
chromosome segregation
microtubule cytoskeleton organization
cell division
mitotic cell cycle process
microtubule-based process
mitotic cell cycle
cell cycle process
cytoskeleton organization
cell cycle