FANCM

Gene Information

Official Symbol: FANCM
Official Name: FA complementation group M
Aliases and Previous Symbols: N/A
Entrez ID: 57697
UniProt: Q8IYD8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
UniProt Summary: DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Olaparib 4μM R08 exp512	-2.25
Rucaparib 6.5μM R08 exp520	-1.81
Colchicine 0.009μM R05 exp215	1.76
Rifampicin 1μM R00 exp31	1.8
Thalidomide 20μM R07 exp406	2.37
Nutlin-3A 1.6μM R06 exp294	5.25

Gene	Correlation
STRA13	0.507
DIDO1	0.457
PSMB4	0.457
CDC73	0.444
FANCF	0.437
POLR2J3	0.429
TICRR	0.418
CHAF1A	0.417
RAD21	0.416
AQR	0.414
ISCU	0.413
SF3A1	0.413
MT1E	0.408
PSAP	0.408
TFRC	0.404
APITD1	0.403
COPE	0.403
ELMOD3	0.402
RBM39	0.401
FDX1L	0.4
AAAS	0.4

Global Fraction of Cell Lines Where Essential: 14/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	4/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	1/1
gastric	1/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	2/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1086
Expression level (log2 read counts): 5.79

Expression Distribution

Helicase C
ResIII
DEAD

FANCM-MHF complex
positive regulation of protein monoubiquitination
regulation of protein monoubiquitination
nuclease activity
Fanconi anaemia nuclear complex
resolution of meiotic recombination intermediates
meiotic chromosome separation
chromosome separation
replication fork processing
DNA-dependent DNA replication maintenance of fidelity
reciprocal meiotic recombination
homologous recombination
interstrand cross-link repair
RNA helicase activity
meiotic chromosome segregation
meiosis I
meiosis I cell cycle process
positive regulation of protein ubiquitination
DNA-dependent DNA replication
positive regulation of protein modification by small protein conjugation or removal
meiotic nuclear division
meiotic cell cycle process
regulation of protein ubiquitination
DNA replication
nuclear chromosome segregation
DNA recombination
meiotic cell cycle
regulation of protein modification by small protein conjugation or removal
chromosome segregation
nuclear division
nucleic acid phosphodiester bond hydrolysis
organelle fission
chromatin binding
DNA repair
DNA metabolic process
cellular response to DNA damage stimulus
cell cycle process
positive regulation of protein modification process
cell cycle
reproductive process