TICRR

Gene Information

Official Symbol: TICRR
Official Name: TOPBP1 interacting checkpoint and replication regulator
Aliases and Previous Symbols: N/A
Entrez ID: 90381
UniProt: Q7Z2Z1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre- initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
6-Thio-2-deoxyguanosine 2μM R06 exp259	-2.05
Vinblastine 0.015μM R05 exp208	-1.87
Chloramphenicol 20μM R00 exp13	1.7
Dexamethasone 0.006μM R07 exp351	1.73
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.74
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.77
GSK-J4 1-1.25μM to day4 R07 exp363	1.89
ETC-159 50μM R08 exp480	1.93
HMS-I1 1μM R01 exp46	1.95
Nicotinamide 2000μM R01 exp50	1.95
UM131593 0.1μM R01 exp58	2.04
BI-2536 0.001μM R01 exp41	2.38
2-Methoxyestradiol 0.2μM R01 exp40	2.77

Gene	Correlation
TCEB3C	0.624
POLR2J3	0.617
TCEB3CL2	0.61
TCEB3CL	0.604
VASN	0.581
PRIM1	0.579
TFIP11	0.569
C1QTNF9B	0.567
CHD4	0.566
COPB1	0.561
CBWD3	0.559
PSMA6	0.556
TBC1D3H	0.553
ANKLE2	0.553
TBC1D3G	0.55
CDCA3	0.546
ATP6AP2	0.543
CHAF1A	0.543
TWISTNB	0.543
TBC1D3F	0.543
ORC6	0.543
C14orf93	0.541
SUPT5H	0.536
PSMB4	0.536
CBWD5	0.531
SUPT6H	0.531
RRN3	0.527
NUPL1	0.525
COL2A1	0.525
COPG1	0.523
NUP160	0.523
TBC1D3C	0.522
SLC4A1	0.521
DOCK6	0.519
ZNF655	0.518
DTL	0.518
CBWD6	0.515
TIMELESS	0.514
PSMD3	0.512
TYMS	0.51
GAR1	0.507
AQR	0.504
CDC6	0.504
SART1	0.502
ORC1	0.502
NPIPB5	0.501
ATP6V0C	0.501
KCTD17	0.499
CDC73	0.497
HIST1H2BE	0.496
IK	0.496
TBC1D3	0.495
PLK1	0.495
PSMC5	0.495
NOL10	0.495
TBC1D3E	0.494
TBC1D3I	0.494
WDR75	0.493
TBC1D3K	0.493
TBC1D3L	0.492
CGB2	0.491
COPA	0.49
KRT78	0.49
CCDC94	0.488
PSMC1	0.487
GOLGA6A	0.487
GPRIN2	0.487
HNRNPC	0.485
COPE	0.485
WDR87	0.484
ZNF106	0.484
GID4	0.484
PSMB3	0.483
EXOSC9	0.483
RAD21	0.482
RIOK2	0.48
AAMP	0.48
POLA2	0.479
CCNA2	0.478
CEP192	0.478
PSMB2	0.476
MED14	0.476
SF3A1	0.476
ARCN1	0.476
POLE	0.476
SLC6A17	0.475
DDTL	0.475
GOLGA6L3	0.474
RPL6	0.473
ATP6AP1	0.473
PSMC2	0.471
MPHOSPH10	0.471
MT1E	0.47
RPS2	0.469
RBM39	0.469
RPS19BP1	0.467
NBPF10	0.467
NOL12	0.466
NUP153	0.466
PAN3	0.466
RAD51	0.466
DIDO1	0.465
RPL35	0.464
ACSF2	0.464
POLR1A	0.464
ZNF830	0.463
UPF1	0.462
PSMD8	0.462
PIGS	0.461
NARFL	0.461
ATP6V1A	0.459
GOLGA8O	0.459
AATF	0.458
NUP43	0.457
GOLGA6L4	0.457
FAM160A1	0.457
SF3A3	0.457
OSBP	0.456
MED17	0.455
NOL8	0.453
HIVEP3	0.453
NPIPB8	0.453
PSMD7	0.452
RRP15	0.452
MYO1H	0.452
SSH2	0.452
TP53TG3B	0.452
GOLGA6L1	0.452
ZNF574	0.452
TP53TG3	0.451
TP53TG3C	0.451
RPS12	0.45
PSMB1	0.45
MDN1	0.45
NSF	0.449
ISCU	0.449
OR10G3	0.449
EXD1	0.447
RFXANK	0.447
PCF11	0.447
FBXO5	0.447
SMG7	0.446
SNRPA1	0.446
STIL	0.446
RNF113A	0.446
SNIP1	0.446
FAM231C	0.445
GON4L	0.445
KIAA0947	0.444
FAM231A	0.444
PDE4DIP	0.444
RPL34	0.444
PSMD1	0.443
PAF1	0.443
RPL26	0.441
KPNB1	0.44
CACTIN	0.44
CDC45	0.439
NAPA	0.439
DHX38	0.438
AKIRIN2	0.438
VPS54	0.438
TGFBRAP1	0.438
SEC13	0.437
PPM1D	0.437
PRPF19	0.437
NUMA1	0.436
RILPL2	0.435
BYSL	0.434
MBTD1	0.434
CCDC116	0.434
HAP1	0.434
RPL3L	0.433
ZFAND5	0.433
INTS6	0.433
WDR43	0.432
NUFIP2	0.432
SH3BP1	0.432
VPS28	0.432
POLR2D	0.432
POLA1	0.432
SAP30BP	0.431
CCDC64B	0.431
ATP6V1C1	0.431
PAN2	0.431
PSMC6	0.431
SMG1	0.431
SYT9	0.431
UBAP1	0.43
IGFN1	0.43
DDT	0.429
RPS5	0.429
CLN6	0.429
PPFIA4	0.428
MYH2	0.428
CDH24	0.428
ANKLE1	0.427
STRN	0.427
RPL9	0.427
PWP2	0.427
RPS7	0.426
COPB2	0.425
TRAIP	0.425
ATP6V0B	0.425
RPL30	0.425
RBBP5	0.424
UTP3	0.424
PSAP	0.423
RRP7A	0.423
DNM2	0.423
SULT2B1	0.423
RPS3A	0.422
HIST1H4B	0.421
PNO1	0.42
PLXNB3	0.42
PPIE	0.419
CWC22	0.418
PSMD11	0.418
TSPY8	0.418
FANCM	0.418
FBXW9	0.418
PSMC4	0.417
SNRNP70	0.417
DDX47	0.416
HINFP	0.416
CMYA5	0.416
RPL10A	0.416
SFPQ	0.415
EXOSC3	0.413
DDX21	0.412
POLD1	0.412
FCN2	0.412
CTAGE4	0.411
COPZ1	0.41
POLR2J2	0.41
NCKAP1L	0.41
NDC80	0.41
PLK4	0.409
POLR2H	0.409
MTCH2	0.408
SPRR2B	0.407
POLR2J	0.407
TOP1MT	0.407
DISP2	0.407
PSMD14	0.407
DNTTIP2	0.407
INTS5	0.406
COX8A	0.406
LRR1	0.406
MKI67IP	0.406
NFATC4	0.405
DDX41	0.405
RRM2	0.405
EIF4A3	0.404
MDM2	0.404
BAGE	0.404
TUBA8	0.404
BAGE3	0.404
PSMA1	0.403
BAGE5	0.403
BAGE4	0.403
OGFR	0.403
BAGE2	0.403
XYLT2	0.401
EBNA1BP2	0.401
POLR2A	0.401
RANGAP1	0.401
CHMP2A	0.401
S1PR4	0.401
CHCHD3	0.401
MCF2L	0.4

Global Fraction of Cell Lines Where Essential: 602/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	23/28
bone	22/25
breast	26/33
central nervous system	46/56
cervix	3/4
colorectal	16/17
esophagus	7/13
fibroblast	1/1
gastric	12/15
kidney	16/21
liver	15/20
lung	63/75
lymphocyte	12/14
ovary	23/26
pancreas	22/24
peripheral nervous system	13/16
plasma cell	10/15
prostate	1/1
skin	18/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	19/22
urinary tract	23/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 1468
Expression level (log2 read counts): 7.51

Expression Distribution

regulation of DNA-dependent DNA replication initiation
mitotic DNA replication checkpoint
formation of translation preinitiation complex
DNA replication checkpoint
mitotic G2/M transition checkpoint
cytoplasmic translational initiation
regulation of DNA-dependent DNA replication
cytoplasmic translation
negative regulation of G2/M transition of mitotic cell cycle
negative regulation of cell cycle G2/M phase transition
mitotic DNA integrity checkpoint
regulation of DNA replication
translational initiation
DNA integrity checkpoint
response to ionizing radiation
mitotic cell cycle checkpoint
cell cycle checkpoint
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
negative regulation of mitotic cell cycle phase transition
DNA replication
negative regulation of cell cycle phase transition
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
regulation of DNA metabolic process
translation
chromatin binding
peptide biosynthetic process
regulation of mitotic cell cycle phase transition
response to radiation
regulation of cell cycle phase transition
ribonucleoprotein complex biogenesis
DNA repair
amide biosynthetic process
peptide metabolic process
negative regulation of cell cycle
mitotic cell cycle process
regulation of mitotic cell cycle