ZFAND5

Gene Information

Official Symbol: ZFAND5
Official Name: zinc finger AN1-type containing 5
Aliases and Previous Symbols: N/A
Entrez ID: 7763
UniProt: O76080
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in protein degradation via the ubiquitin- proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4- induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269|PubMed:14754897}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Latrunculin-B 10μM R07 exp374	-2.97
Etoposide 0.3μM R05 exp199	-2.64
BVD-523 15μM R02 exp67	-2.43
CB-5083 0.4μM R08 exp468	-2.41
Dinaciclib 0.007μM R07 exp355	-2.41
Hippuristanol 0.12μM R08 exp488	-2.41
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.41
SNS-032 15μM R08 exp443	-2.39
Benzoate 20000μM R08 exp456	-2.33
Nocodazole 0.2μM R02 exp64	-2.32
Thapsigargin 0.005μM R07 exp407	-2.28
Tanespimycin 14μM R08 exp527	-2.27
LY2090314 0.003μM R08 exp500 no dilution day6	-2.26
MS023 7μM R03 exp135	-2.19
RO-3307 4.7μM R02 exp80	-2.19
42°C R08 exp539	-2.11
Pimelic-diphenylamide-106 5μM R00 exp28	-2.1
Aphidicolin 0.4μM R08 exp440	-2.09
GSK461364A 0.1μM R03 exp126	-2.03
Bleomycin 5μM R08 exp459	-2.02
DABN racemic mixture R03 exp93	-2.02
6-Thio-2-deoxyguanosine 2μM R06 exp259	-2.01
Ammonium tetrathiomolybdate 10μM R08 exp448	-2
Aminopterin 0.005μM R07 exp335	-1.98
Thimerosal 0.85μM R08 exp529	-1.97
2-Deoxy-D-glucose 800μM R05 exp214	-1.93
GSK626616 14μM R08 exp485	-1.93
HMS-I1 10μM R06 exp256	-1.9
UM0129480 7μM R02 exp85	-1.87
Citral 75μM R06 exp275	-1.86
SB743921 0.001μM R05 exp244	-1.84
AICAR 240μM R03 exp116	-1.72
Rifampicin 1μM R00 exp31	1.72
Tunicamycin 0.04μM R07 exp418	1.72
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.74
Rapamycin 10μM R00 exp30	1.74
DABN 2μM R00 exp16	1.87
Cycloheximide 0.02μM R00 exp14	1.97
Adefovir 20μM R07 exp332	2.19
Metformin 100 to 150μM on day4 R04 exp170	2.51

Gene	Correlation
SMG7	0.677
BCL2L1	0.65
ATP13A1	0.612
PSMC2	0.608
SMG1	0.599
PSMD1	0.591
PSMC1	0.569
MYO1H	0.564
PSMA6	0.559
TBC1D3H	0.558
SSH2	0.549
PSMD11	0.548
CHD4	0.546
MDM2	0.543
VASN	0.542
SUPT6H	0.542
PAN3	0.541
TBC1D3G	0.54
DDTL	0.539
TBC1D3C	0.526
PSMC6	0.519
SCAF1	0.512
RPS28	0.51
SMG5	0.51
RNPC3	0.507
TCEB3CL2	0.503
PSMD14	0.503
PSMB4	0.503
PAN2	0.503
TBC1D3F	0.503
NUPL1	0.502
CDK12	0.502
PSMD2	0.501
ZNF106	0.498
TWISTNB	0.497
ANKLE2	0.496
C1QTNF9B	0.496
CDC73	0.495
HAP1	0.495
RANBP2	0.495
RAD51	0.492
DTL	0.489
LAD1	0.488
NOP16	0.487
RPL30	0.486
MED17	0.485
EXOSC9	0.485
NUP85	0.484
UPF1	0.483
PSMC4	0.483
PAF1	0.482
RNF4	0.482
CDCA3	0.481
CCNA2	0.481
SLC38A7	0.48
SLC6A17	0.478
CBWD3	0.477
ANKLE1	0.477
POLA2	0.477
RPS12	0.475
SLC4A1	0.474
WDR43	0.474
ZNF830	0.474
PSMB3	0.472
RPL35	0.472
MBTD1	0.472
C14orf93	0.471
DNM2	0.471
CDT1	0.469
PSMD3	0.468
TERF2	0.468
TBC1D3	0.468
SEL1L	0.468
PSMD6	0.468
RRN3	0.467
PSMA7	0.465
PLCG2	0.465
RNF121	0.465
ADRM1	0.464
NBPF10	0.463
RPL14	0.463
AKIRIN2	0.462
TCEB3C	0.462
CHMP2A	0.461
AHCTF1	0.461
RBM39	0.458
POLR2J3	0.458
CACTIN	0.457
IK	0.457
SH3BP1	0.457
PSMB1	0.457
CDC45	0.456
DISP2	0.455
KPNB1	0.455
TBC1D3I	0.455
TBC1D3E	0.455
MT1E	0.455
TBC1D3K	0.455
RPS2	0.455
OGFR	0.455
CCDC64B	0.455
PSMA1	0.454
TBC1D3L	0.454
CBWD5	0.453
POLR2D	0.453
TRAIP	0.453
DHX9	0.453
CHCHD3	0.451
MED14	0.45
ARCN1	0.45
PSMB2	0.449
COPA	0.449
FAM86B2	0.448
RAD21	0.448
AAAS	0.447
PSMD13	0.446
RPS9	0.445
CHMP4B	0.444
NBPF16	0.443
PSMC3	0.443
SYT9	0.442
ATXN1	0.439
POLE	0.439
SETD1A	0.439
MTCH2	0.439
MYH7B	0.439
ACBD4	0.438
PCF11	0.437
HIVEP3	0.437
FBXO5	0.437
COL2A1	0.436
COPE	0.436
RPS3	0.435
PSMD7	0.435
PRPF8	0.434
NARFL	0.434
HIST2H2BF	0.434
PWP2	0.434
TICRR	0.433
RBBP5	0.433
UBXN4	0.432
RPL38	0.432
ISCU	0.431
DOCK6	0.43
RPSA	0.43
RPL34	0.43
TP53TG3B	0.43
KCTD17	0.429
GOLGA8O	0.429
RNF113A	0.429
TCEB3CL	0.429
ORC6	0.429
RPL6	0.429
TP53TG3	0.428
SULT2B1	0.428
UPF2	0.428
FBXW9	0.428
TERF1	0.428
EBNA1BP2	0.428
TP53TG3C	0.427
CBWD6	0.427
CNOT1	0.427
AQR	0.426
NAPA	0.425
DNTTIP2	0.424
ACSF2	0.424
C19orf53	0.424
EXOSC5	0.424
COPG1	0.424
SEC13	0.424
LRR1	0.424
MKI67IP	0.423
KRT78	0.422
CKAP5	0.421
KLHL12	0.42
RRP15	0.42
SUPT5H	0.419
MMS22L	0.418
SMG6	0.418
NSF	0.418
MORC2	0.417
PDE4DIP	0.416
COPB1	0.416
RPS14	0.415
IGFN1	0.415
UBE4A	0.415
MUL1	0.415
CCDC94	0.415
NUP153	0.415
TTC1	0.415
TRA2B	0.414
DDT	0.414
NUP188	0.414
RPA2	0.413
CCDC116	0.412
UBL5	0.412
NOL12	0.412
RPL7L1	0.412
NUP205	0.412
NUP43	0.411
NAALADL1	0.411
RSL1D1	0.41
SNIP1	0.41
NDC1	0.409
CLPX	0.409
RFPL3	0.408
ARID2	0.408
NOL10	0.407
NUP54	0.407
BCL2L2	0.407
MED12	0.406
S1PR4	0.406
DDX56	0.406
CTR9	0.406
NUP133	0.406
COX8A	0.406
DYNC1I2	0.406
AAMP	0.406
MAP7D1	0.405
CHAF1A	0.404
RPS20	0.403
DHX38	0.403
TFIP11	0.402
CACNA1A	0.402
RAN	0.401
DDX21	0.401
ORC1	0.4
EGR2	0.4
RPS19BP1	0.4
TOP1MT	0.4
BOD1L1	0.4
ZNF655	0.4
RFC1	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1400
Expression level (log2 read counts): 6.67

Expression Distribution

zf-A20
zf-AN1

cellular component
molecular function
zinc ion binding
DNA binding