POLA2

Gene Information

Official Symbol: POLA2
Official Name: DNA polymerase alpha 2, accessory subunit
Aliases and Previous Symbols: N/A
Entrez ID: 23649
UniProt: Q14181
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 20μM R00 exp26	-2.36
GSK461364A 0.1μM R03 exp126	-2.29
5-Fluorouracil 20μM R00 exp2	-2.22
MK-1775 0.32μM R02 exp75	-2.21
Pimelic-diphenylamide-106 5μM R00 exp28	-2.11
Lead acetate 2000μM R08 exp498 no dilution day6	-1.94
DABN 20μM R00 exp17	-1.91
AICAR 240μM R03 exp116	-1.8
Brefeldin A 0.02μM R00 exp8	-1.73
Deguelin 0.15μM R05 exp209	1.71
FBS-Wisent 0.1 R07 exp426	1.73
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.75
Doxycycline 10μM R00 exp18	1.75
HMS-I1 1μM R01 exp46	1.77
Nifuroxazide 5μM R03 exp102	1.78
Pomalidomide 20μM R07 exp391	1.78
Lenalidomide 20μM R07 exp375	1.79
Bortezomib 0.005μM R00 exp6	1.81
BI-2536 0.001μM R01 exp41	1.82
Chloramphenicol 2μM R00 exp12	1.82
Isoniazid 100μM R08 exp494	1.82
L-BMAA 500 to 750μM on day4 R04 exp185	1.83
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.86
Nocodazole 0.02μM R00 exp23	1.86
BI-2536 0.0042μM R03 exp95	1.89
Salubrinal 20μM R07 exp399	1.9
Dexamethasone 0.006μM R07 exp351	1.92
BH1 1μM R04 exp169	1.94
ABT-702 5μM R06 exp261	1.95
All-trans-Retinoic-Acid 8μM R07 exp333	1.99
Rifampicin 10μM R00 exp32	1.99
GSK-J4 1-1.25μM to day4 R07 exp363	2.03
Docosahexaenoic-acid 50μM R07 exp356	2.06
HMS-I2 10μM R06 exp288	2.11
PT-1 25μM R07 exp392	2.25
Lapatinib 5μM R01 exp47	2.51
CCCP 1μM R00 exp11	2.53
NFN1 0.1μM R01 exp49	2.55
GSK-J4 1μM R07 exp362	2.66
Apcin 50 to 100μM on day4 R04 exp176	2.68

Gene	Correlation
ORC6	0.546
TBC1D3G	0.543
DIDO1	0.532
TBC1D3H	0.526
TBC1D3F	0.521
VASN	0.516
PSMB4	0.512
CHD4	0.511
SUPT6H	0.509
TCEB3CL2	0.507
TRAIP	0.507
KRT78	0.501
RPL35	0.501
TCEB3C	0.499
HIST2H3C	0.498
HIST2H3A	0.498
PSMA6	0.497
SMG1	0.497
TBC1D3C	0.492
CDCA3	0.491
HAP1	0.491
RBBP5	0.491
PRIM1	0.49
CDC73	0.49
RPS2	0.49
PSMD11	0.489
C14orf93	0.486
RPS3A	0.485
RPL7A	0.485
RAD21	0.485
WDR43	0.484
GOLGA8O	0.483
TBC1D3	0.48
PCF11	0.479
UPF1	0.479
TICRR	0.479
RPL6	0.478
ZFAND5	0.477
NBPF10	0.476
SLC4A1	0.473
TCEB3CL	0.471
SSH2	0.47
RRP15	0.467
CBWD3	0.467
SF3A1	0.467
SMG7	0.465
ORC1	0.465
PSMB3	0.462
CDC45	0.462
POLR1A	0.461
TWISTNB	0.46
POLR2J3	0.46
RRN3	0.459
DDX56	0.458
DDTL	0.458
COL2A1	0.458
NPIPB5	0.456
TSPY1	0.456
NARFL	0.454
MYO1H	0.454
RPS5	0.452
TBC1D3L	0.452
TBC1D3K	0.452
TBC1D3E	0.451
GGA3	0.451
CBWD5	0.451
TBC1D3I	0.451
KCTD17	0.45
AAMP	0.45
WDR75	0.448
RPL14	0.448
RPA2	0.446
CCDC116	0.446
RAD51	0.446
DTL	0.445
PAN3	0.445
PAF1	0.444
PSMD1	0.444
CWC22	0.444
MT1E	0.444
CTAGE4	0.442
EXOSC6	0.442
ZNF655	0.44
ANKLE2	0.439
SLC6A17	0.439
IGFN1	0.438
C1QTNF9B	0.437
PSAP	0.437
CTR9	0.436
RPS9	0.435
CBWD6	0.435
PRPF8	0.435
ZNF106	0.434
IK	0.433
MPHOSPH10	0.433
SNRPA1	0.432
PPFIA4	0.432
CDC6	0.432
MYB	0.431
NUPL1	0.431
COPE	0.429
SNRNP70	0.429
NIP7	0.428
PSMA7	0.428
PSMB2	0.428
POLR2J	0.427
RPS12	0.427
RPS7	0.426
TFIP11	0.426
FAM160A1	0.425
AKIRIN2	0.424
RPL9	0.424
PAN2	0.423
SSRP1	0.423
STIL	0.422
NOL10	0.422
POLA1	0.419
RBM39	0.419
PWP2	0.419
ATP6AP1	0.418
URB2	0.418
NCAPG	0.417
ISCU	0.417
PSMC1	0.417
ACSF2	0.417
NUP160	0.416
NHP2L1	0.416
RNF4	0.415
AHCTF1	0.415
CKAP5	0.414
CHCHD3	0.414
RPS3	0.414
PSMD3	0.414
SF3A3	0.412
CACNA1A	0.412
ELMOD3	0.412
BRD2	0.412
DDX47	0.411
INTS6	0.411
NIPBL	0.411
ATP6V1C1	0.411
PSMC2	0.41
RNF113A	0.41
UBL5	0.409
PPIE	0.409
CACTIN	0.408
HIST1H2BE	0.408
RILPL2	0.408
COPA	0.407
OGFR	0.407
SNRNP200	0.407
TTYH1	0.407
PSMD14	0.407
RPS28	0.406
RPL7L1	0.405
BYSL	0.405
NUP133	0.404
SCAF1	0.404
RNF121	0.403
UTP20	0.403
NUP62	0.402
SFPQ	0.402
AQR	0.402
RANBP2	0.402
NUP43	0.402
PSMC6	0.402
KRT2	0.401
NUP153	0.401
CASC3	0.401
COPB2	0.401
MED17	0.4
PSMB1	0.4
POLE	0.4

Global Fraction of Cell Lines Where Essential: 410/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	17/28
blood	13/28
bone	16/26
breast	20/33
central nervous system	32/56
cervix	3/4
colorectal	15/17
esophagus	4/13
fibroblast	1/1
gastric	3/16
kidney	11/21
liver	16/20
lung	40/75
lymphocyte	9/16
ovary	16/26
pancreas	12/24
peripheral nervous system	11/16
plasma cell	5/15
prostate	1/1
skin	7/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	3/22
urinary tract	14/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 334
Expression level (log2 read counts): 6.59

Expression Distribution

DNA pol E B
Pol alpha B N

alpha DNA polymerase:primase complex
telomere maintenance via semi-conservative replication
DNA-directed DNA polymerase activity
DNA replication initiation
nuclear DNA replication
cell cycle DNA replication
telomere maintenance
telomere organization
DNA biosynthetic process
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
DNA-dependent DNA replication
DNA replication
mitotic cell cycle phase transition
cell cycle phase transition
anatomical structure homeostasis
protein heterodimerization activity
mitotic cell cycle process
mitotic cell cycle
DNA metabolic process
molecular function
cellular homeostasis
cell cycle process
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cell cycle
DNA binding
cellular nitrogen compound biosynthetic process
homeostatic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process