PPIE

Entrez Summary: The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 111/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	6/28
blood	2/28
bone	1/26
breast	5/33
central nervous system	7/56
cervix	0/4
colorectal	3/17
esophagus	4/13
fibroblast	0/1
gastric	5/16
kidney	4/21
liver	2/20
lung	13/75
lymphocyte	2/16
ovary	2/26
pancreas	2/24
peripheral nervous system	5/16
plasma cell	0/15
prostate	1/1
skin	1/24
soft tissue	3/9
thyroid	1/2
upper aerodigestive	3/22
urinary tract	5/29
uterus	1/5

Expression Distribution

Pro isomerase
RRM 1

poly(A) binding
cyclosporin A binding
U2-type catalytic step 2 spliceosome
positive regulation of viral genome replication
protein refolding
peptidyl-prolyl cis-trans isomerase activity
protein peptidyl-prolyl isomerization
peptidyl-proline modification
positive regulation of viral life cycle
transcription-coupled nucleotide-excision repair
catalytic step 2 spliceosome
regulation of viral genome replication
positive regulation of viral process
nucleotide-excision repair
secretory granule lumen
ficolin-1-rich granule lumen
unfolded protein binding
regulation of viral life cycle
mRNA binding
regulation of viral process
regulation of symbiosis, encompassing mutualism through parasitism
protein folding
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
mRNA processing
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
DNA repair
positive regulation of multi-organism process
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response