PPIE [The Human Chemical-Genetic Interaction Map Project]

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======= PPIE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPIE
  * **<color #00a2e8>Official Name</color>**: peptidylprolyl isomerase E
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10450|10450]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UNP9|Q9UNP9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPIE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPIE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602435|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pro isomerase|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|poly(A) binding|
|cyclosporin A binding|
|U2-type catalytic step 2 spliceosome|
|positive regulation of viral genome replication|
|protein refolding|
|peptidyl-prolyl cis-trans isomerase activity|
|protein peptidyl-prolyl isomerization|
|peptidyl-proline modification|
|positive regulation of viral life cycle|
|transcription-coupled nucleotide-excision repair|
|catalytic step 2 spliceosome|
|regulation of viral genome replication|
|positive regulation of viral process|
|nucleotide-excision repair|
|secretory granule lumen|
|ficolin-1-rich granule lumen|
|unfolded protein binding|
|regulation of viral life cycle|
|mRNA binding|
|regulation of viral process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|protein folding|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|DNA repair|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|mRNA metabolic process|
|regulated exocytosis|
|DNA metabolic process|
|leukocyte mediated immunity|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|exocytosis|
|RNA processing|
|peptidyl-amino acid modification|
|leukocyte activation|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|RNA binding|
|RNA metabolic process|
|cellular response to stress|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.75|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.76|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cactin|CACTIN]]|0.469|
|[[:human genes:r:rpl38|RPL38]]|0.444|
|[[:human genes:p:psmd3|PSMD3]]|0.44|
|[[:human genes:c:cbwd3|CBWD3]]|0.431|
|[[:human genes:c:cdca3|CDCA3]]|0.43|
|[[:human genes:c:ckap5|CKAP5]]|0.426|
|[[:human genes:t:tfip11|TFIP11]]|0.425|
|[[:human genes:s:supt5h|SUPT5H]]|0.424|
|[[:human genes:s:srsf1|SRSF1]]|0.422|
|[[:human genes:c:cdk8|CDK8]]|0.421|
|[[:human genes:t:ticrr|TICRR]]|0.419|
|[[:human genes:p:psmc5|PSMC5]]|0.419|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.419|
|[[:human genes:r:rpl35|RPL35]]|0.418|
|[[:human genes:i:ik|IK]]|0.417|
|[[:human genes:n:narfl|NARFL]]|0.417|
|[[:human genes:r:rbm39|RBM39]]|0.417|
|[[:human genes:n:nip7|NIP7]]|0.415|
|[[:human genes:s:setd1a|SETD1A]]|0.413|
|[[:human genes:p:psmb2|PSMB2]]|0.411|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.41|
|[[:human genes:p:pola2|POLA2]]|0.409|
|[[:human genes:c:cwc22|CWC22]]|0.408|
|[[:human genes:p:psmb4|PSMB4]]|0.406|
|[[:human genes:c:cdc6|CDC6]]|0.406|
|[[:human genes:r:rpl34|RPL34]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 111/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|2/28|
|bone|1/26|
|breast|5/33|
|central nervous system|7/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|4/21|
|liver|2/20|
|lung|13/75|
|lymphocyte|2/16|
|ovary|2/26|
|pancreas|2/24|
|peripheral nervous system|5/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|3/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 438
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPIE Expression in NALM6 Cells: 5.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>