TBC1D3H

Gene Information

Official Symbol: TBC1D3H
Official Name: TBC1 domain family member 3H
Aliases and Previous Symbols: N/A
Entrez ID: 729877
UniProt: P0C7X1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
POLR2J3	0.668
PSMA6	0.651
TCEB3CL2	0.633
RPS2	0.629
C1QTNF9B	0.623
TFIP11	0.619
DTL	0.614
TCEB3CL	0.61
TCEB3C	0.601
CHD4	0.6
SYT9	0.583
AQR	0.583
VASN	0.582
CBWD3	0.581
RRN3	0.581
C14orf93	0.572
DDTL	0.57
ANKLE1	0.565
SSH2	0.565
CBWD5	0.565
MT1E	0.558
ZFAND5	0.558
RRP7A	0.556
PSMD3	0.556
PPFIA4	0.553
TICRR	0.553
CCNA2	0.551
PSMB4	0.549
RPS12	0.549
PSMC1	0.548
NUPL1	0.547
RAD51	0.544
RBBP5	0.542
EXOSC5	0.542
LRR1	0.54
FCN2	0.54
RFXANK	0.538
SUPT5H	0.538
MCOLN1	0.536
SLC4A1	0.536
S1PR4	0.535
TWISTNB	0.534
CACTIN	0.531
RPS28	0.53
ZNF106	0.529
NPIPB5	0.529
ORC6	0.528
RPL35	0.527
POLA2	0.526
UPF1	0.525
SLC6A17	0.525
MADCAM1	0.524
PCF11	0.523
TRAIP	0.523
SEC13	0.522
NOP16	0.522
PSMB2	0.522
PSMD2	0.521
KCTD17	0.52
POLR2D	0.519
MYO1H	0.519
CDC45	0.518
SUPT6H	0.517
CCDC94	0.517
IGFN1	0.516
CGB2	0.516
UTP3	0.514
HIVEP3	0.514
ANKLE2	0.513
TONSL	0.512
CBWD6	0.512
EXOSC8	0.512
STIL	0.512
MED29	0.511
NUP43	0.51
FAM160A1	0.509
TIMELESS	0.509
OGFR	0.509
MYB	0.508
NUP153	0.508
IK	0.507
MED14	0.506
CDC73	0.506
TSPY1	0.506
EXOSC9	0.505
PSMA7	0.504
ARHGEF35	0.504
NOL12	0.503
ELMOD3	0.503
SH3BP1	0.502
WDR87	0.501
RNF4	0.501
HIST2H2BF	0.501
ACSF2	0.498
MMS22L	0.498
NARFL	0.498
AAMP	0.498
CHAF1A	0.498
COL2A1	0.497
RPL6	0.497
KRT78	0.496
TPX2	0.495
TYMS	0.495
EGR2	0.494
RPL34	0.493
CDC6	0.493
RPS19BP1	0.493
NAPA	0.492
ORC1	0.492
CHMP2A	0.491
SNRPA1	0.491
PSMC2	0.49
SART1	0.49
KIF3C	0.49
POLR2A	0.488
ATP6V1A	0.487
PLA2G4F	0.487
RBM39	0.486
EXOSC3	0.486
CMYA5	0.486
ZNF830	0.486
AKIRIN2	0.485
SEL1L	0.485
ADD2	0.485
RPS20	0.485
MYT1L	0.484
PSMD11	0.484
PSMB1	0.484
COPB1	0.483
RPS5	0.483
PRPF8	0.483
SF3A1	0.481
MED17	0.48
POLE	0.48
CCDC116	0.48
TGM5	0.479
WDR43	0.479
NBPF10	0.479
RAD21	0.479
RFPL3	0.478
PSMC6	0.478
EBNA1BP2	0.478
COPE	0.477
CDCA3	0.477
VPS28	0.476
CTR9	0.475
NOL10	0.475
GOLGA6A	0.474
XYLT2	0.474
LAD1	0.473
NUP85	0.473
PSMD6	0.473
TRIM52	0.472
GOLGA6L1	0.472
ZNF655	0.471
PSMD1	0.471
PDE4DIP	0.471
RIOK2	0.47
CACNA1A	0.47
NUP160	0.469
TP53TG3B	0.469
CCDC64B	0.468
FAM231A	0.468
COPG1	0.468
ZNF541	0.468
FAM231C	0.468
DNM2	0.467
TP53TG3C	0.467
C2orf27B	0.467
GOLGA6B	0.467
FBXW9	0.467
TP53TG3	0.467
RPL9	0.467
ART5	0.467
TSPY2	0.467
CEP192	0.466
RPA2	0.466
SMG7	0.466
DDX56	0.466
PAN2	0.466
PRPF19	0.466
FAM20A	0.466
HAP1	0.465
POLA1	0.465
ZNF219	0.465
BYSL	0.465
POLR2L	0.464
PWP2	0.464
DHX38	0.464
PBXIP1	0.464
MDM2	0.464
DOCK6	0.464
SMG1	0.464
RPS14	0.463
PSMD8	0.463
DISP2	0.463
AATF	0.463
PSMD14	0.463
MYH2	0.462
TSPY8	0.462
PSMB3	0.461
NFATC4	0.461
SLC5A5	0.461
NUP133	0.461
UQCRH	0.461
CKAP5	0.461
ATP6V1C1	0.461
MED12	0.46
CHCHD3	0.46
PSMD7	0.46
ITGA2B	0.46
POLR1A	0.46
ATP13A1	0.46
RANBP2	0.459
HIST1H2BE	0.459
MYH7B	0.458
GOLGA8O	0.458
TP53TG3D	0.458
DNTTIP2	0.457
UTP20	0.457
CTAGE4	0.456
ISCU	0.456
PAF1	0.456
XAB2	0.455
RPS7	0.454
BCL2L1	0.454
RFC1	0.454
MAT2A	0.454
KPNB1	0.453
COPZ1	0.453
RPL14	0.452
PSMC4	0.452
MSH5	0.452
PRIM1	0.452
BRD4	0.452
CNOT1	0.451
SLC38A7	0.451
RRP15	0.45
CHMP4B	0.45
RANGAP1	0.45
HIST2H3A	0.45
HIST2H3C	0.45
SCAF1	0.449
FAM25B	0.449
NUP54	0.449
NDC80	0.448
SFPQ	0.448
ATP6V0B	0.447
RPS9	0.446
SULT1A3	0.445
TTC1	0.445
INTS6	0.444
SPRR2B	0.444
LOC643669	0.444
STRN	0.444
SULT1A4	0.444
HCFC1	0.443
TOPBP1	0.443
COPA	0.443
APC2	0.442
TUBA8	0.442
GOLGA6L3	0.442
EXD1	0.442
UTP18	0.442
RPL30	0.441
CDH24	0.441
OR10G3	0.441
VPS52	0.441
POLR2J	0.441
TSG101	0.441
CDT1	0.441
USP36	0.44
AHCTF1	0.44
RPL7L1	0.439
MYLK3	0.439
AKAP1	0.438
TOP1MT	0.438
VPS54	0.437
PSMC5	0.437
GBF1	0.437
MFRP	0.437
FAM86B2	0.437
ATP6V0C	0.436
EIF4A3	0.436
PAN3	0.436
CLN6	0.436
NPIPB8	0.435
SULT2B1	0.434
MBTD1	0.434
WDR75	0.434
ACBD4	0.433
HINFP	0.432
USPL1	0.432
ZNF574	0.432
GOLGA6L4	0.432
PLK1	0.431
PSMA1	0.431
MYO18A	0.43
GID4	0.43
ATXN1	0.43
GAR1	0.429
AAAS	0.429
FBL	0.429
GPRIN2	0.427
PLEKHA4	0.427
RNF113A	0.426
SAP30BP	0.426
GOSR2	0.424
SNIP1	0.424
POLD1	0.424
RHBDD3	0.423
GOLGA6L6	0.423
CWC15	0.423
PIGS	0.422
PSAP	0.422
CNPY3	0.422
WDR90	0.422
NUP62	0.421
POLR2F	0.421
RRP1	0.42
ATP6AP2	0.42
NSF	0.42
NUP107	0.42
COX7A2L	0.42
SNRNP70	0.418
TTK	0.418
SF3A2	0.418
TRAPPC11	0.418
ABHD8	0.417
PLK4	0.416
DDX47	0.416
RPS10	0.415
INTS5	0.415
HIST1H3I	0.415
MFSD12	0.415
CASC5	0.415
RPL10A	0.414
SF3A3	0.414
SETD1A	0.414
RNPC3	0.414
NUP205	0.414
EXOSC6	0.413
TAGLN	0.413
EIF3G	0.413
NUF2	0.413
TTC31	0.413
SEMA6B	0.413
C2orf27A	0.412
ADRA1D	0.412
DDT	0.412
NDC1	0.412
C3orf17	0.411
APRT	0.41
PPIE	0.41
COL4A2	0.409
HNRNPC	0.409
SSX3	0.409
NOL7	0.408
ATP6AP1	0.407
OSBP	0.407
GRAMD1A	0.407
MCF2L	0.406
DYNC1I2	0.406
ABT1	0.406
COX8A	0.406
GGA3	0.406
RPS3A	0.405
NAALADL1	0.405
DIEXF	0.405
RFFL	0.404
SPRR2A	0.404
CGB8	0.403
BRIX1	0.403
POLR2J2	0.403
CGB5	0.403
NFYA	0.403
GNL2	0.403
RPSA	0.402
OGDH	0.402
NIP7	0.402
PSMD13	0.402
TERF2	0.402
RPLP1	0.402
OR11H6	0.401
TERF1	0.401
FBXL19	0.4
NCAPG	0.4
CDK9	0.4
LIPE	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1678
Expression level (log2 read counts): 1.59

Expression Distribution

Screen	Score
Apcin 50 to 100μM on day4 R04 exp176	1.79
RO-3306 3 to 4μM on day4 R04 exp165	1.91

activation of GTPase activity
Rab GTPase binding
GTPase activator activity
positive regulation of GTPase activity
regulation of GTPase activity
positive regulation of hydrolase activity
intracellular protein transport
regulation of hydrolase activity
positive regulation of catalytic activity
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
positive regulation of molecular function
establishment of localization in cell
nitrogen compound transport