PDE4DIP

Entrez Summary: The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dexamethasone 0.006μM R07 exp351	1.71
Thalidomide 20μM R07 exp406	1.75
39°C R06 exp303	1.76
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.77
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.78
Chlorpromazine 10μM R07 exp344	1.91

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of Golgi organization
myofibril
molecular adaptor activity
enzyme binding
centrosome
cellular protein-containing complex assembly
Golgi apparatus
regulation of organelle organization
protein-containing complex assembly
protein-containing complex subunit organization