UM0130462 0.025 to 0.035μM day4 R05 exp247
Mechanism of Action
Unknown
- Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit
Technical Notes
Compound References
- PubChem Name: 1-Chloro-2-(2-chloroethyl)-3-methylpyrido[1,2-a]benzimidazole-4-carbonitrile
- Synonyms: N/A
- CAS #: 166671-24-5
- PubChem CID: 373493
- IUPAC: 1-chloro-2-(2-chloroethyl)-3-methylpyrido[1,2-a]benzimidazole-4-carbonitrile
- INCHI Name: InChI=1S/C15H11Cl2N3/c1-9-10(6-7-16)14(17)20-13-5-3-2-4-12(13)19-15(20)11(9)8-18/h2-5H,6-7H2,1H3
- INCHI Key: FUFPNFLKYVGOQV-UHFFFAOYSA-N
- Molecular Weight: 304.17
- Canonical SMILES: CC1=C(C2=NC3=CC=CC=C3N2C(=C1CCCl)Cl)C#N
- Isomeric SMILES: N/A
- Molecular Formula: C15H11N3Cl2
Compound Supplier
- Supplier Name: In house - University of Montreal - Chemistry Platform
- Catalog #: N/A
- Lot #: IRIC-009 / JFL-2177-020 / Batch #01
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C15H11Cl2N3 304.04028; found 304.0396
Dose Response Curve
- Platform ID: UM0130462
- Min: 28.7491; Max: 99.0794
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | 0.0107 |
| IC40 | 0.0169 |
| IC50 | 0.0256 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 05
- Dose: 0.025-0.035µM
- Days of incubation: 8
- Doublings: 7.4
- Numbers of reads: 20933112
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
UM0130462 0.025 to 0.035μM day4 R05 exp247
UM0130462 0.025 to 0.035μM day4 R05 exp247 vs proTAME 5μM R04 exp187
PFI-2 4μM R05 exp239 vs UM0130462 0.025 to 0.035μM day4 R05 exp247
Apcin 25μM plus proTAME 2μM R04 exp177 vs UM0130462 0.025 to 0.035μM day4 R05 exp247
