NABP2

Entrez Summary: N/A
UniProt Summary: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

C-rich strand telomeric DNA binding
SOSS complex
establishment of protein localization to telomere
G-rich strand telomeric DNA binding
protein localization to chromosome, telomeric region
establishment of protein localization to chromosome
positive regulation of telomere capping
DNA polymerase binding
regulation of telomere capping
positive regulation of telomere maintenance
regulation of telomerase activity
protein localization to chromosome
snRNA transcription by RNA polymerase II
snRNA transcription
regulation of telomere maintenance
ncRNA transcription
double-strand break repair via homologous recombination
recombinational repair
single-stranded DNA binding
nuclear chromosome, telomeric region
regulation of DNA biosynthetic process
response to ionizing radiation
mitotic cell cycle checkpoint
positive regulation of chromosome organization
double-strand break repair
positive regulation of DNA metabolic process
cell cycle checkpoint
DNA recombination
negative regulation of mitotic cell cycle
regulation of chromosome organization
regulation of DNA metabolic process
establishment of protein localization to organelle
response to radiation
transcription by RNA polymerase II
DNA repair
negative regulation of cell cycle
mitotic cell cycle process
positive regulation of organelle organization
regulation of mitotic cell cycle
transcription, DNA-templated